What is the recommended dosage for L-Citrulline?

L Citrulline: 3,000-6,000 mg/day; Citrulline Malate: 6,000-8,000 mg/day; Blood Pressure Support: 3,000 mg/day

What are the side effects of L-Citrulline?

Potential side effects include: Generally well-tolerated, Mild gastrointestinal discomfort at high doses, Heartburn (rare).

What is L-citrulline and how may it support cardiovascular health?

L-citrulline is an amino acid that is converted to L-arginine in the kidneys, raising plasma arginine and nitric oxide levels more effectively than arginine itself. Clinical studies suggest it may improve endothelial function, reduce arterial stiffness, and modestly lower blood pressure.

What dosage of L-citrulline has been studied for cardiovascular outcomes?

Clinical trials have used 3–6 grams of L-citrulline per day, or citrulline malate at 6–8 grams daily. Blood pressure benefits were observed at doses of 3+ grams daily for 4–8 weeks. L-citrulline raises arginine levels more sustainably than L-arginine supplementation due to bypassing first-pass metabolism.

What are the potential side effects of L-citrulline?

L-citrulline is generally well tolerated with few reported side effects. Mild gastrointestinal discomfort may occur at higher doses. As a nitric oxide precursor, it may enhance the effects of blood pressure medications and nitrates (including PDE5 inhibitors like sildenafil). Individuals on antihypertensives should consult a healthcare provider.

L-Citrulline

amino_acid

Also known as: Citrulline, Citrulline Malate, L-Citrulline DL-Malate

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'heartcited.com'; const params = 'ingredient\u003Dl\u002Dcitrulline'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

About

L-Citrulline is converted to L-arginine in the kidneys, bypassing hepatic first-pass metabolism and maintaining sustained plasma arginine levels more effectively than direct arginine supplementation. A 2019 meta-analysis of 7 RCTs found L-citrulline at 3-6g/day significantly reduced systolic blood pressure by 4.1 mmHg.

How It Works

Converted to L-arginine in the kidneys bypassing hepatic first-pass metabolism, maintaining sustained plasma arginine levels; this recycling pathway maintains nitric oxide production more effectively than direct arginine supplementation; citrulline also buffers ammonia during high-demand cardiac states.

Evidence For Conditions

Condition	Grade	Studies	Participants
High Blood Pressure (Hypertension)	C	7	400	View →

Side Effects

Generally well-tolerated
Mild gastrointestinal discomfort at high doses
Heartburn (rare)

Drug & Supplement Interactions

Antihypertensives (additive blood pressure lowering)
PDE5 inhibitors (excessive vasodilation risk)
Nitrates (excessive vasodilation risk)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

L-Arginine Nattokinase Taurine

Quick Facts

Dosage: L_Citrulline: 3,000-6,000 mg/day; Citrulline_Malate: 6,000-8,000 mg/day; Blood_Pressure_Support: 3,000 mg/day
Forms: capsule powder tablet
Natural Sources: Watermelon (highest food source, especially rind), Cucumbers, Pumpkin, Squash
Upper Limit: Not formally established; well-tolerated up to 15,000 mg/day in clinical trials
Best Time: On empty stomach; divide doses for sustained arginine elevation

Evidence Summary

High Blood Pressure (Hypertension) C

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.