What is the recommended dosage for Grape Seed Extract?

General: 100-300 mg/day; Blood Pressure Support: 150-300 mg/day standardized to 95% OPCs

What are the side effects of Grape Seed Extract?

Potential side effects include: Generally well-tolerated, Mild headache (rare), Dizziness (rare), Nausea (rare).

What is grape seed extract and how may it support cardiovascular health?

Grape seed extract is rich in oligomeric proanthocyanidins (OPCs), potent antioxidants that may improve endothelial function and reduce oxidative stress. Meta-analyses of clinical trials suggest grape seed extract may modestly reduce systolic blood pressure and heart rate. It may also support healthy LDL oxidation resistance.

What dosage of grape seed extract has been studied for cardiovascular benefits?

Clinical trials have used 100–600 mg of grape seed extract per day, standardized to 80–95% OPCs. Blood pressure benefits were observed in meta-analyses at doses of 100–300 mg daily for 8–16 weeks. Higher doses have not shown proportionally greater benefits.

What are the potential side effects of grape seed extract?

Grape seed extract is generally well tolerated. Mild side effects include headache, sore throat, and digestive discomfort. It may increase bleeding risk when combined with blood thinners. Individuals with grape allergies should avoid this supplement. Drug interactions are possible with anticoagulants and NSAIDs.

Grape Seed Extract
Grape Seed Extract

antioxidant

Aussi connu sous le nom de: OPC, Oligomeric Proanthocyanidins, Proanthocyanidin, Vitis vinifera Extract

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Grape seed extract is a rich source of oligomeric proanthocyanidins (OPCs) with antioxidant capacity 20-50x greater than vitamins C and E. A 2016 meta-analysis of 16 RCTs (810 participants) found it significantly reduced systolic blood pressure by 6.08 mmHg, with greater effects in younger and obese participants.

How It Works

Rich source of oligomeric proanthocyanidins (OPCs) that inhibit LDL oxidation with potency exceeding vitamins C and E; enhances endothelial nitric oxide production; inhibits ACE in a manner similar to pharmaceutical ACE inhibitors; reduces platelet aggregation; strengthens capillary walls.

Evidence For Conditions

Pathologie	Note	Études	Participants
High Blood Pressure (Hypertension)	B	16	810	Voir →
Endothelial Dysfunction	C	6	350	Voir →

Side Effects

Generally well-tolerated
Mild headache (rare)
Dizziness (rare)
Nausea (rare)

Drug & Supplement Interactions

Anticoagulants (may increase bleeding risk)
Blood pressure medications (additive hypotensive effect)
Iron supplements (tannins may reduce iron absorption)

Informez toujours votre professionnel de santé de tous les compléments alimentaires que vous prenez.Informez toujours votre professionnel de santé de tous les compléments que vous prenez.

Related Ingredients

Resveratrol Astaxanthin Quercetin Lycopene

En bref

Posologie: General: 100-300 mg/day; Blood_Pressure_Support: 150-300 mg/day standardized to 95% OPCs
Formes: capsule tablet liquid extract
Sources naturelles: Grape seeds, Red wine, Pine bark (related Pycnogenol), Cranberries, Cacao
Limite supérieure: Not formally established; up to 600 mg/day used in clinical trials
Meilleur moment: With or without food

Synthèse des preuves

High Blood Pressure (Hypertension) B

Endothelial Dysfunction C

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.