What is the recommended dosage for Grape Seed Extract?

General: 100-300 mg/day; Blood Pressure Support: 150-300 mg/day standardized to 95% OPCs

What are the side effects of Grape Seed Extract?

Potential side effects include: Generally well-tolerated, Mild headache (rare), Dizziness (rare), Nausea (rare).

What is grape seed extract and how may it support cardiovascular health?

Grape seed extract is rich in oligomeric proanthocyanidins (OPCs), potent antioxidants that may improve endothelial function and reduce oxidative stress. Meta-analyses of clinical trials suggest grape seed extract may modestly reduce systolic blood pressure and heart rate. It may also support healthy LDL oxidation resistance.

What dosage of grape seed extract has been studied for cardiovascular benefits?

Clinical trials have used 100–600 mg of grape seed extract per day, standardized to 80–95% OPCs. Blood pressure benefits were observed in meta-analyses at doses of 100–300 mg daily for 8–16 weeks. Higher doses have not shown proportionally greater benefits.

What are the potential side effects of grape seed extract?

Grape seed extract is generally well tolerated. Mild side effects include headache, sore throat, and digestive discomfort. It may increase bleeding risk when combined with blood thinners. Individuals with grape allergies should avoid this supplement. Drug interactions are possible with anticoagulants and NSAIDs.

Grape Seed Extract
Grape Seed Extract

antioxidant

अन्य नाम: OPC, Oligomeric Proanthocyanidins, Proanthocyanidin, Vitis vinifera Extract

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Grape seed extract is a rich source of oligomeric proanthocyanidins (OPCs) with antioxidant capacity 20-50x greater than vitamins C and E. A 2016 meta-analysis of 16 RCTs (810 participants) found it significantly reduced systolic blood pressure by 6.08 mmHg, with greater effects in younger and obese participants.

How It Works

Rich source of oligomeric proanthocyanidins (OPCs) that inhibit LDL oxidation with potency exceeding vitamins C and E; enhances endothelial nitric oxide production; inhibits ACE in a manner similar to pharmaceutical ACE inhibitors; reduces platelet aggregation; strengthens capillary walls.

Evidence For Conditions

स्वास्थ्य स्थिति	ग्रेड	अध्ययन	प्रतिभागी
High Blood Pressure (Hypertension)	B	16	810	देखें →
Endothelial Dysfunction	C	6	350	देखें →

Side Effects

Generally well-tolerated
Mild headache (rare)
Dizziness (rare)
Nausea (rare)

Drug & Supplement Interactions

Anticoagulants (may increase bleeding risk)
Blood pressure medications (additive hypotensive effect)
Iron supplements (tannins may reduce iron absorption)

अपने स्वास्थ्य सेवा प्रदाता को आप जो भी सप्लीमेंट लेते हैं उनके बारे में हमेशा सूचित करें।

Related Ingredients

Resveratrol Astaxanthin Quercetin Lycopene

त्वरित तथ्य

खुराक: General: 100-300 mg/day; Blood_Pressure_Support: 150-300 mg/day standardized to 95% OPCs
रूप: capsule tablet liquid extract
प्राकृतिक स्रोत: Grape seeds, Red wine, Pine bark (related Pycnogenol), Cranberries, Cacao
अधिकतम सीमा: Not formally established; up to 600 mg/day used in clinical trials
सर्वोत्तम समय: With or without food

साक्ष्य सारांश

High Blood Pressure (Hypertension) B

Endothelial Dysfunction C

FDA अस्वीकरण: इन कथनों का Food and Drug Administration द्वारा मूल्यांकन नहीं किया गया है। इस वेबसाइट पर उत्पादों और जानकारी का उद्देश्य किसी बीमारी का निदान, उपचार, इलाज या रोकथाम नहीं है। प्रस्तुत साक्ष्य ग्रेड प्रकाशित पीयर-रिव्यूड अनुसंधान के हमारे विश्लेषण पर आधारित हैं और चिकित्सा सलाह नहीं हैं। कोई भी सप्लीमेंट शुरू करने से पहले हमेशा अपने स्वास्थ्य सेवा प्रदाता से परामर्श करें।