What is the recommended dosage for Grape Seed Extract?

General: 100-300 mg/day; Blood Pressure Support: 150-300 mg/day standardized to 95% OPCs

What are the side effects of Grape Seed Extract?

Potential side effects include: Generally well-tolerated, Mild headache (rare), Dizziness (rare), Nausea (rare).

What is grape seed extract and how may it support cardiovascular health?

Grape seed extract is rich in oligomeric proanthocyanidins (OPCs), potent antioxidants that may improve endothelial function and reduce oxidative stress. Meta-analyses of clinical trials suggest grape seed extract may modestly reduce systolic blood pressure and heart rate. It may also support healthy LDL oxidation resistance.

What dosage of grape seed extract has been studied for cardiovascular benefits?

Clinical trials have used 100–600 mg of grape seed extract per day, standardized to 80–95% OPCs. Blood pressure benefits were observed in meta-analyses at doses of 100–300 mg daily for 8–16 weeks. Higher doses have not shown proportionally greater benefits.

What are the potential side effects of grape seed extract?

Grape seed extract is generally well tolerated. Mild side effects include headache, sore throat, and digestive discomfort. It may increase bleeding risk when combined with blood thinners. Individuals with grape allergies should avoid this supplement. Drug interactions are possible with anticoagulants and NSAIDs.

Grape Seed Extract
Grape Seed Extract

antioxidant

Также известен как: OPC, Oligomeric Proanthocyanidins, Proanthocyanidin, Vitis vinifera Extract

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Grape seed extract is a rich source of oligomeric proanthocyanidins (OPCs) with antioxidant capacity 20-50x greater than vitamins C and E. A 2016 meta-analysis of 16 RCTs (810 participants) found it significantly reduced systolic blood pressure by 6.08 mmHg, with greater effects in younger and obese participants.

How It Works

Rich source of oligomeric proanthocyanidins (OPCs) that inhibit LDL oxidation with potency exceeding vitamins C and E; enhances endothelial nitric oxide production; inhibits ACE in a manner similar to pharmaceutical ACE inhibitors; reduces platelet aggregation; strengthens capillary walls.

Evidence For Conditions

Состояние	Оценка	Исследования	Участники
High Blood Pressure (Hypertension)	B	16	810	Подробнее →
Endothelial Dysfunction	C	6	350	Подробнее →

Side Effects

Generally well-tolerated
Mild headache (rare)
Dizziness (rare)
Nausea (rare)

Drug & Supplement Interactions

Anticoagulants (may increase bleeding risk)
Blood pressure medications (additive hypotensive effect)
Iron supplements (tannins may reduce iron absorption)

Всегда сообщайте лечащему врачу обо всех принимаемых добавках.

Related Ingredients

Resveratrol Astaxanthin Quercetin Lycopene

Основные факты

Дозировка: General: 100-300 mg/day; Blood_Pressure_Support: 150-300 mg/day standardized to 95% OPCs
Формы выпуска: capsule tablet liquid extract
Природные источники: Grape seeds, Red wine, Pine bark (related Pycnogenol), Cranberries, Cacao
Верхний предел: Not formally established; up to 600 mg/day used in clinical trials
Лучшее время приёма: With or without food

Обзор доказательной базы

High Blood Pressure (Hypertension) B

Endothelial Dysfunction C

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.