What is the recommended dosage for Grape Seed Extract?

General: 100-300 mg/day; Blood Pressure Support: 150-300 mg/day standardized to 95% OPCs

What are the side effects of Grape Seed Extract?

Potential side effects include: Generally well-tolerated, Mild headache (rare), Dizziness (rare), Nausea (rare).

What is grape seed extract and how may it support cardiovascular health?

Grape seed extract is rich in oligomeric proanthocyanidins (OPCs), potent antioxidants that may improve endothelial function and reduce oxidative stress. Meta-analyses of clinical trials suggest grape seed extract may modestly reduce systolic blood pressure and heart rate. It may also support healthy LDL oxidation resistance.

What dosage of grape seed extract has been studied for cardiovascular benefits?

Clinical trials have used 100–600 mg of grape seed extract per day, standardized to 80–95% OPCs. Blood pressure benefits were observed in meta-analyses at doses of 100–300 mg daily for 8–16 weeks. Higher doses have not shown proportionally greater benefits.

What are the potential side effects of grape seed extract?

Grape seed extract is generally well tolerated. Mild side effects include headache, sore throat, and digestive discomfort. It may increase bleeding risk when combined with blood thinners. Individuals with grape allergies should avoid this supplement. Drug interactions are possible with anticoagulants and NSAIDs.

Grape Seed Extract
Grape Seed Extract

antioxidant

Còn được gọi là: OPC, Oligomeric Proanthocyanidins, Proanthocyanidin, Vitis vinifera Extract

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'heartcited.com'; const params = 'ingredient\u003Dgrape\u002Dseed\u002Dextract'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

About

Grape seed extract is a rich source of oligomeric proanthocyanidins (OPCs) with antioxidant capacity 20-50x greater than vitamins C and E. A 2016 meta-analysis of 16 RCTs (810 participants) found it significantly reduced systolic blood pressure by 6.08 mmHg, with greater effects in younger and obese participants.

How It Works

Rich source of oligomeric proanthocyanidins (OPCs) that inhibit LDL oxidation with potency exceeding vitamins C and E; enhances endothelial nitric oxide production; inhibits ACE in a manner similar to pharmaceutical ACE inhibitors; reduces platelet aggregation; strengthens capillary walls.

Evidence For Conditions

Tình trạng	Xếp hạng	Nghiên cứu	Người tham gia
High Blood Pressure (Hypertension)	B	16	810	Xem →
Endothelial Dysfunction	C	6	350	Xem →

Side Effects

Generally well-tolerated
Mild headache (rare)
Dizziness (rare)
Nausea (rare)

Drug & Supplement Interactions

Anticoagulants (may increase bleeding risk)
Blood pressure medications (additive hypotensive effect)
Iron supplements (tannins may reduce iron absorption)

Luôn thông báo cho bác sĩ về tất cả các thực phẩm bổ sung bạn đang sử dụng.Luôn thông báo cho chuyên gia y tế về tất cả thực phẩm chức năng bạn đang sử dụng.

Related Ingredients

Resveratrol Astaxanthin Quercetin Lycopene

Thông tin nhanh

Liều lượng: General: 100-300 mg/day; Blood_Pressure_Support: 150-300 mg/day standardized to 95% OPCs
Dạng bào chế: capsule tablet liquid extract
Nguồn tự nhiên: Grape seeds, Red wine, Pine bark (related Pycnogenol), Cranberries, Cacao
Giới hạn trên: Not formally established; up to 600 mg/day used in clinical trials
Thời điểm tốt nhất: With or without food

Tóm tắt bằng chứng

High Blood Pressure (Hypertension) B

Endothelial Dysfunction C

Tuyên bố miễn trừ FDA: Các tuyên bố này chưa được Cục Quản lý Thực phẩm và Dược phẩm (FDA) đánh giá. Các sản phẩm và thông tin trên trang web này không nhằm mục đích chẩn đoán, điều trị, chữa bệnh hoặc phòng ngừa bất kỳ bệnh nào. Xếp hạng bằng chứng được trình bày dựa trên phân tích của chúng tôi về nghiên cứu đã bình duyệt được công bố và không cấu thành tư vấn y khoa. Luôn tham khảo ý kiến chuyên gia y tế trước khi bắt đầu bất kỳ chế độ thực phẩm chức năng nào.