L-Arginine para Heart Failure

Q: Does L-Arginine help with Heart Failure?

Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).

Q: How much L-Arginine should I take for Heart Failure?

Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of L-Arginine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for L-Arginine and Heart Failure?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

D Investigación Solo existe investigación preliminar (estudios de laboratorio, informes de casos).

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

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Conclusión

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Key Study Findings

Review

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.

Dose: None vs: None Outcome: None Efecto: None None

Población: Humans (general)

animal_study

Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the …

Dose: NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) vs: Placebo Efecto: NM and WA exerted moderate vasorelaxant effect (less than ACh); augmented ACh-induced relaxation; in not_reported

In Vitro

Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.

Dose: astaxanthin vs: L-NAME-induced preeclamptic rats Outcome: oxidative stress and blood pressure Efecto: reduced ROS and improved cell survival None

Población: Preeclamptic rat model and HUVECs

In Vitro 1.0 weeks

Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.

Dose: 10 mg/kg vs: None Outcome: anxiety Efecto: None p < 0.05

Población: patients with anxiety

Other 1.0 weeks

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic …

Dose: None vs: None Outcome: Nitric oxide modulation mediates the protective effect of … Efecto: None p<0.05

Población: None

Review

Immunonutrition.

Dose: Glutamine, omega-3, antioxidants, arginine vs: None Outcome: Immune function and clinical outcomes Efecto: None None

Población: Surgical, ICU, cancer, Crohn's disease patients

Key Statistics

Estudios

150

Participantes

↔

Mixed

Calificación

Referenced Papers

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Other

Advances in experimental … 2021 206 citas

Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … Other

Journal of ethnopharmacology 2021 18 citas

Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. Other

Molecular medicine reports 2016 48 citas

Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. Other

Indian journal of … 2011 11 citas

Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. Other

Pharmacological reports : … 2008

Immunonutrition. Review

Current opinion in … 2005 22 citas

Arginine and cancer. Review

The Journal of … 2004 181 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

endothelialfunction:: 3,000-6,000 mg/day
bloodpressuresupport:: 6,000-10,000 mg/day divided BID-TID

Límite superior: Not formally established; GI discomfort common above 10,000 mg/day

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
None	--	Mixed	--
NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA)	--	Positive	--
astaxanthin	--	Positive	--
10 mg/kg	1.0 weeks	Positive	--
None	1.0 weeks	Mixed	--
Glutamine, omega-3, antioxidants, arginine	--	Positive	--
L-arginine	--	Mixed	--

Mejor momento para tomar: On empty stomach for best absorption; divide doses throughout the day

Safety & Side Effects

Efectos secundarios reportados

⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
⚠ Hypotension at high doses
⚠ Worsening of herpes simplex (arginine promotes viral replication)
⚠ Potential harm in acute post-MI patients (VINTAGE MI concern)

Interacciones conocidas

● Antihypertensives (additive blood pressure lowering)
● PDE5 inhibitors (sildenafil — excessive vasodilation risk)
● Nitrates (excessive vasodilation risk)
● Anticoagulants (may have mild antiplatelet effect)
● Potassium-sparing diuretics (arginine may increase potassium levels)

Ingesta máxima tolerable: Not formally established; GI discomfort common above 10,000 mg/day

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does L-Arginine help with Heart Failure?

Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).

How much L-Arginine should I take for Heart Failure?

Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of L-Arginine?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for L-Arginine and Heart Failure?

We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

Otros ingredientes para Heart Failure

Coenzyme Q10 (CoQ10) B Hawthorn B Vitamin D C Taurine C PQQ (Pyrroloquinoline Quinone) D NMN (Nicotinamide Mononucleotide) D

L-Arginine para otras condiciones

Endothelial Dysfunction C

Veredicto rápido

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Evidence Strength30%

Low confidence

Desglose de estudios

RCT (0)Meta (0)Other (3)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para Heart Failure

Más información

References

[1] Guoyao Wu et al.. Adv Exp Med Biol. 2021. Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. doi:10.1007/978-3-030-74180-8_10 PubMed
[2] Priya Pathak et al.. J Ethnopharmacol. 2021. Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … doi:10.1016/j.jep.2021.114296 PubMed
[3] Rong-Rong Xuan et al.. Mol Med Rep. 2016. Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. doi:10.3892/mmr.2016.5569 PubMed
[4] Anil Kumar et al.. Indian J Pharmacol. 2011. Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. doi:10.4103/0253-7613.81506 PubMed
[5] Anil Kumar et al.. Pharmacol Rep. 2008. Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. PubMed
[6] Robert F Grimble. Curr Opin Gastroenterol. 2005. Immunonutrition. doi:10.1097/01.mog.0000153360.90653.82 PubMed
[7] D Scott Lind. J Nutr. 2004. Arginine and cancer. doi:10.1093/jn/134.10.2837S PubMed

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.

L-Arginine para Heart Failure

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Conclusión

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Dosificaciones de uso común

Dosificaciones estudiadas en la investigación

Safety & Side Effects

Efectos secundarios reportados

Interacciones conocidas

Frequently Asked Questions

Related Evidence

Otros ingredientes para Heart Failure

L-Arginine para otras condiciones

References