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HeartCited

Selenium
Selenium

mineral

다른 이름: Selenomethionine, Sodium Selenite, Selenium Yeast, L-Selenomethionine

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About





            

                
Selenium is an essential component of glutathione peroxidases, the primary enzymatic antioxidant defense against lipid peroxidation in vascular tissue. The KiSel-10 trial (443 elderly participants, 4 years) found combined selenium (200 mcg/day) and CoQ10 reduced cardiovascular mortality by 54%, with effects persisting for 12 years. A U-shaped dose-response exists: serum selenium of 120-150 mcg/L appears optimal.

            

        

        

        
        
        

            

  
How It Works





            

                
Essential component of selenoprotein P and glutathione peroxidases (GPx) — the primary enzymatic antioxidant defense against lipid peroxidation and LDL oxidation in vascular tissue; thioredoxin reductases regulate vascular redox signaling; selenoprotein S modulates endoplasmic reticulum stress in cardiomyocytes; adequate selenium status supports thyroid function influencing cardiac output.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                건강 상태
                                등급
                                연구
                                참여자
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Oxidative Stress (Cardiovascular)
                                    
                                
                                
                                    B

                                
                                
                                    3
                                
                                
                                    600
                                
                                
                                    
                                        보기 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Coronary Artery Disease (CAD)
                                    
                                
                                
                                    C

                                
                                
                                    5
                                
                                
                                    10000
                                
                                
                                    
                                        보기 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Selenosis at high doses (garlic breath odor, hair/nail loss, nausea)
                
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  • 
                    
                    GI discomfort at moderate-high doses
                
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  • 
                    
                    Potential increased type 2 diabetes risk at high supplemental doses
                
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Drug & Supplement Interactions





            
    
                
                
  • 
                    
                    Cisplatin and other chemotherapy drugs (may affect efficacy)
                
    • 
                
                
  • 
                    
                    Statins (may enhance antioxidant effects)
                
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  • 
                    
                    CoQ10 (synergistic cardiovascular benefit — KiSel-10 combination)
                
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                복용 중인 모든 건강기능식품에 대해 반드시 의료 전문가에게 알리십시오.
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Magnesium
                    
                
                
                
                    Potassium
                    
                
                
                
                    Calcium
                    
                
                
            

        

        
    


    
    












    

        FDA 면책 조항:
        이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.