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HeartCited

Selenium
Selenium

mineral

别名: Selenomethionine, Sodium Selenite, Selenium Yeast, L-Selenomethionine

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About





            

                
Selenium is an essential component of glutathione peroxidases, the primary enzymatic antioxidant defense against lipid peroxidation in vascular tissue. The KiSel-10 trial (443 elderly participants, 4 years) found combined selenium (200 mcg/day) and CoQ10 reduced cardiovascular mortality by 54%, with effects persisting for 12 years. A U-shaped dose-response exists: serum selenium of 120-150 mcg/L appears optimal.

            

        

        

        
        
        

            

  
How It Works





            

                
Essential component of selenoprotein P and glutathione peroxidases (GPx) — the primary enzymatic antioxidant defense against lipid peroxidation and LDL oxidation in vascular tissue; thioredoxin reductases regulate vascular redox signaling; selenoprotein S modulates endoplasmic reticulum stress in cardiomyocytes; adequate selenium status supports thyroid function influencing cardiac output.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        Oxidative Stress (Cardiovascular)
                                    
                                
                                
                                    B

                                
                                
                                    3
                                
                                
                                    600
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                            

                                
                                    
                                        Coronary Artery Disease (CAD)
                                    
                                
                                
                                    C

                                
                                
                                    5
                                
                                
                                    10000
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Selenosis at high doses (garlic breath odor, hair/nail loss, nausea)
                
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                    GI discomfort at moderate-high doses
                
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  • 
                    
                    Potential increased type 2 diabetes risk at high supplemental doses
                
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Drug & Supplement Interactions





            
    
                
                
  • 
                    
                    Cisplatin and other chemotherapy drugs (may affect efficacy)
                
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                    Statins (may enhance antioxidant effects)
                
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                    CoQ10 (synergistic cardiovascular benefit — KiSel-10 combination)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Magnesium
                    
                
                
                
                    Potassium
                    
                
                
                
                    Calcium
                    
                
                
            

        

        
    


    
    












    

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