What is the recommended dosage for Quercetin?

General: 500-1,000 mg/day; Blood Pressure Support: 500-730 mg/day

What are the side effects of Quercetin?

Potential side effects include: Generally well-tolerated, Headache (rare), Mild gastrointestinal discomfort, Tingling in extremities (rare, high doses).

What is quercetin and how may it support cardiovascular health?

Quercetin is a flavonoid found in onions, apples, and berries with antioxidant and anti-inflammatory properties. Meta-analyses of RCTs suggest quercetin may reduce blood pressure, particularly in hypertensive individuals. It may also improve endothelial function and reduce LDL oxidation.

What dosage of quercetin has been studied for cardiovascular benefits?

Clinical trials have used 100–1,000 mg of quercetin per day. Blood pressure reductions were most consistent at doses of 500 mg or higher daily for at least 8 weeks. Quercetin dihydrate and quercetin-3-glucoside are commonly studied forms. Bioavailability may be improved with co-administration of vitamin C.

What are the potential side effects of quercetin?

Quercetin is generally well tolerated at doses up to 1,000 mg daily. Side effects are rare but may include headache and tingling in extremities. Quercetin may interact with antibiotics (fluoroquinolones), cyclosporine, and drugs metabolized by CYP3A4. Very high doses may have pro-oxidant effects.

Quercetin

antioxidant

Also known as: Quercetin Dihydrate, Quercetin Phytosome, Isoquercetin

𝕏 LinkedIn

<\/script>\n

`; }, get iframeSnippet() { const domain = 'heartcited.com'; const params = 'ingredient\u003Dquercetin'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style

Widget powered by . Free, no account required.

About

Quercetin is a ubiquitous dietary flavonoid that reduces blood pressure through endothelium-dependent nitric oxide release and ACE inhibition. A 2020 meta-analysis of 17 RCTs found quercetin at >=500 mg/day reduced systolic blood pressure by 3.09 mmHg and diastolic by 2.86 mmHg, with greater effects in hypertensive subjects.

How It Works

Inhibits LDL oxidation and foam cell formation; reduces blood pressure through direct vasorelaxation via endothelium-dependent nitric oxide release; inhibits ACE activity; anti-inflammatory via NF-kB, COX-2, and lipoxygenase inhibition; reduces platelet aggregation; may inhibit PCSK9 expression reducing LDL receptor degradation.

Evidence For Conditions

Condition	Grade	Studies	Participants
High Blood Pressure (Hypertension)	B	17	900	View →
Atherosclerosis	D	2	100	View →

Side Effects

Generally well-tolerated
Headache (rare)
Mild gastrointestinal discomfort
Tingling in extremities (rare, high doses)

Drug & Supplement Interactions

Antibiotics (quinolones — may reduce efficacy)
Cyclosporine (may increase blood levels)
Anticoagulants (may have mild antiplatelet effect)
Blood pressure medications (additive effect)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Astaxanthin Grape Seed Extract Lycopene Resveratrol

Quick Facts

Dosage: General: 500-1,000 mg/day; Blood_Pressure_Support: 500-730 mg/day
Forms: capsule tablet powder
Natural Sources: Onions (especially red), Apples, Berries, Broccoli, Capers, Green tea, Red wine
Upper Limit: Not formally established; up to 1,000 mg/day used in clinical trials
Best Time: With meals; vitamin C co-supplementation may enhance bioavailability

Evidence Summary

High Blood Pressure (Hypertension) B

Atherosclerosis D

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.