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HeartCited

L-Arginine pour Heart Failure

D Recherche Seules des recherches préliminaires existent (études en laboratoire, rapports de cas).

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

D

En conclusion

Small studies show improved exercise capacity. However, safety concerns from the VINTAGE MI trial apply to the broader acute cardiac population. Use with caution.

Key Study Findings

animal_study
Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the …
Dose: NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) vs: Placebo Effet: NM and WA exerted moderate vasorelaxant effect (less than ACh); augmented ACh-induced relaxation; in not_reported
In Vitro
Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.
Dose: astaxanthin vs: L-NAME-induced preeclamptic rats Outcome: oxidative stress and blood pressure Effet: reduced ROS and improved cell survival

Population: Preeclamptic rat model and HUVECs

In Vitro 1.0 weeks
Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.
Dose: 10 mg/kg Outcome: anxiety p < 0.05

Population: patients with anxiety

Review
Immunonutrition.
Dose: Glutamine, omega-3, antioxidants, arginine Outcome: Immune function and clinical outcomes

Population: Surgical, ICU, cancer, Crohn's disease patients

Review
Arginine and cancer.
Dose: L-arginine Outcome: Cancer biology and NO role

Key Statistics

3

Études

150

Participants

↔

Mixed

D

Note

Referenced Papers

Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans. Other
Advances in experimental … 2021 206 citations
Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing … Other
Journal of ethnopharmacology 2021 18 citations
Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation. Other
Molecular medicine reports 2016 48 citations
Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice. Other
Indian journal of … 2011 11 citations
Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome. Other
Pharmacological reports : … 2008
Immunonutrition. Review
Current opinion in … 2005 22 citations
Arginine and cancer. Review
The Journal of … 2004 181 citations

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Posologies couramment utilisées

endothelialfunction:
3,000-6,000 mg/day
bloodpressuresupport:
6,000-10,000 mg/day divided BID-TID

Limite supérieure : Not formally established; GI discomfort common above 10,000 mg/day

Posologies étudiées dans la recherche

Posologie Durée Effet N
NMITLI-118R (Withania somnifera standardized root extract) and Withanolide A (WA) -- Positive --
astaxanthin -- Positive --
10 mg/kg 1.0 weeks Positive --
Glutamine, omega-3, antioxidants, arginine -- Positive --
L-arginine -- Mixed --

Moment optimal de prise : On empty stomach for best absorption; divide doses throughout the day

Safety & Side Effects

Effets indésirables signalés

  • ⚠ Gastrointestinal discomfort (nausea, diarrhea, bloating)
  • ⚠ Hypotension at high doses
  • ⚠ Worsening of herpes simplex (arginine promotes viral replication)
  • ⚠ Potential harm in acute post-MI patients (VINTAGE MI concern)

Interactions connues

  • ● Antihypertensives (additive blood pressure lowering)
  • ● PDE5 inhibitors (sildenafil — excessive vasodilation risk)
  • ● Nitrates (excessive vasodilation risk)
  • ● Anticoagulants (may have mild antiplatelet effect)
  • ● Potassium-sparing diuretics (arginine may increase potassium levels)

Apport maximal tolérable : Not formally established; GI discomfort common above 10,000 mg/day

Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.

Frequently Asked Questions

Does L-Arginine help with Heart Failure?
Based on 3 studies with 150 participants, there is preliminary evidence that needs more research that L-Arginine may support Heart Failure management. Our evidence grade is D (Very Early Research).
How much L-Arginine should I take for Heart Failure?
Studies have used various dosages. A commonly studied range is 3,000-6,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of L-Arginine?
Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, bloating), Hypotension at high doses, Worsening of herpes simplex (arginine promotes viral replication), Potential harm in acute post-MI patients (VINTAGE MI concern). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for L-Arginine and Heart Failure?
We rate the evidence as Grade D (Very Early Research). This rating is based on 3 peer-reviewed studies with 150 total participants. The overall direction of effect is mixed.

L-Arginine pour d'autres pathologies

Endothelial Dysfunction C

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References

  
    
    
    
  1. 
      [1]
      Guoyao Wu et al..
      Adv Exp Med Biol.
      2021.
      Role of L-Arginine in Nitric Oxide Synthesis and Health in Humans.
      doi:10.1007/978-3-030-74180-8_10
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Priya Pathak et al..
      J Ethnopharmacol.
      2021.
      Standardized root extract of Withania somnifera and Withanolide A exert moderate vasorelaxant effect in the rat aortic rings by enhancing …
      doi:10.1016/j.jep.2021.114296
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Rong-Rong Xuan et al..
      Mol Med Rep.
      2016.
      Astaxanthin blocks preeclampsia progression by suppressing oxidative stress and inflammation.
      doi:10.3892/mmr.2016.5569
      PubMed
    
    4. 
    
    
  4. 
      [4]
      Anil Kumar et al..
      Indian J Pharmacol.
      2011.
      Nitric oxide modulation in protective role of antidepressants against chronic fatigue syndrome in mice.
      doi:10.4103/0253-7613.81506
      PubMed
    
    5. 
    
    
  5. 
      [5]
      Anil Kumar et al..
      Pharmacol Rep.
      2008.
      Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome.
      
      PubMed
    
    6. 
    
    
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      [6]
      Robert F Grimble.
      Curr Opin Gastroenterol.
      2005.
      Immunonutrition.
      doi:10.1097/01.mog.0000153360.90653.82
      PubMed
    
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      [7]
      D Scott Lind.
      J Nutr.
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      PubMed
    
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        Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.