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Krill Oil for High Cholesterol (Hyperlipidemia)

C Some Evidence Limited evidence from small studies, but some positive signals exist.

Research suggests reductions in LDL and triglycerides with increases in HDL. Phospholipid-bound EPA/DHA may improve bioavailability. Smaller evidence base than fish oil.

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            C

        

        

            
The Bottom Line

            
            
Research suggests reductions in LDL and triglycerides with increases in HDL. Phospholipid-bound EPA/DHA may improve bioavailability. Smaller evidence base than fish oil.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Other
                
                
                
                
            

            
                Antarctic Krill Euphausia superba Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced …
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Oxidative stress markers
                
                
                Effect: None
                
                
                None
                
            

            
            
Population: Mouse model

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
7

        
Studies

    

    

        
600

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Antarctic Krill Euphausia superba Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2024
                        
                        5 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
500-1,000 mg/day

                    

                    
                    

                        
lipidsupport:

                        
1,000-3,000 mg/day

                    

                    
                

                
                

                    Upper limit: Not formally established; studies have used up to 4,000 mg/day without significant adverse effe
                

                
            

            

            
            

                
Dosages Studied in Research

                

                    

                        
                            

                                Dosage
                                Duration
                                Effect
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Best taken: With meals containing fat
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
  • 
                            ⚠
                            Fishy aftertaste
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild gastrointestinal discomfort
                        
    • 
                        
                        
  • 
                            ⚠
                            Allergic reactions in those with shellfish allergy
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants (may increase bleeding risk)
                        
    • 
                        
                        
  • 
                            ●
                            Blood pressure medications (additive hypotensive effect)
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: Not formally established; studies have used up to 4,000 mg/day without significant adverse effe
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Krill Oil help with High Cholesterol (Hyperlipidemia)?
            
        
        

            Based on 7 studies with 600 participants, there is limited but promising evidence that Krill Oil may support High Cholesterol (Hyperlipidemia) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much Krill Oil should I take for High Cholesterol (Hyperlipidemia)?
            
        
        

            Studies have used various dosages. A commonly studied range is 500-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Krill Oil?
            
        
        

            Reported side effects may include Fishy aftertaste, Mild gastrointestinal discomfort, Allergic reactions in those with shellfish allergy. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Krill Oil and High Cholesterol (Hyperlipidemia)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 7 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                
                

                
                

                    
Krill Oil for other conditions

                    

                        
                        
                            Cardiovascular Inflammation
                            D

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Jun-Hui Choi et al..
      Nutrients.
      2024.
      Antarctic Krill Euphausia superba Oil Supplementation Attenuates Hypercholesterolemia, Fatty Liver, and Oxidative Stress in Diet-Induced Obese Mice.
      doi:10.3390/nu16213614
      PubMed
    
    2. 
    
  















    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.