Resveratrol para High Blood Pressure (Hypertension)

Q: Does Resveratrol help with High Blood Pressure (Hypertension)?

Based on 10 studies with 600 participants, there is moderate evidence from clinical studies that Resveratrol may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).

Q: How much Resveratrol should I take for High Blood Pressure (Hypertension)?

Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Q: Are there side effects of Resveratrol?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses, Headache, May have estrogenic activity at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

Q: How strong is the evidence for Resveratrol and High Blood Pressure (Hypertension)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

B Evidencia Al menos un ensayo aleatorizado lo respalda, con resultados mayoritariamente consistentes.

Meta-analysis: systolic -11.9 mmHg in hypertensives at >=150 mg/day. Improved flow-mediated dilation in multiple RCTs. Bioavailability limitations noted.

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Conclusión

Meta-analysis: systolic -11.9 mmHg in hypertensives at >=150 mg/day. Improved flow-mediated dilation in multiple RCTs. Bioavailability limitations noted.

Key Study Findings

Review

Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk.

Dose: None vs: None Outcome: None Efecto: None None

Población: review of nutrition and lifestyle interventions for dyslipidemia and cardiometabolic risk

Review

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues.

Dose: None vs: None Outcome: None Efecto: None None

Población: review of age-related cardiac dysfunction and heart failure mechanisms

Review

Dietary supplements and prevention of preeclampsia.

Dose: 500 mg daily vs: Placebo Outcome: Preeclampsia risk reduction Efecto: ~50% risk reduction None

Población: Pregnant women with low calcium intake

Systematic Review

The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review.

Dose: None vs: Placebo or no treatment Outcome: Cardiometabolic changes in menopausal women Efecto: None None

Población: Menopausal women

Controlled Clinical Trial

Resveratrol inhibits cerebral aneurysms in mice via downregulating the NF-κB pathway.

Dose: None vs: Model group (no RES) and sham control Outcome: Cerebral aneurysm formation Efecto: None P<0.05

Población: Mice with induced hypertension CA model

Review

The Role of Resveratrol Administration in Human Obesity.

Dose: None vs: None Outcome: None Efecto: None None

Población: Obese adults

Key Statistics

Estudios

600

Participantes

↑

Positive

Calificación

Referenced Papers

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues. Review

ESC heart failure 2025 58 citas

Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk. Review

Nutrients 2025 32 citas

Dietary supplements and prevention of preeclampsia. Review

Hypertension research : … 2025 10 citas

The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review. Other

Cardiovascular & hematological … 2025

Resveratrol inhibits cerebral aneurysms in mice via downregulating the NF-κB pathway. Other

Acta biochimica Polonica 2022 10 citas

The Role of Resveratrol Administration in Human Obesity. Review

International journal of … 2021 50 citas

Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. Other

Nutrients 2020 49 citas

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. Other

Nutrients 2020 16 citas

Nutritional prevention of cognitive decline and dementia. Review

Acta bio-medica : … 2018 103 citas

Dosage & Usage

mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units

Dosificaciones de uso común

general:: 150-500 mg/day
cardiovascularsupport:: 250-500 mg/day trans-resveratrol

Límite superior: Not formally established; GI discomfort common above 1,000 mg/day

Dosificaciones estudiadas en la investigación

Dosificación	Duración	Efecto	N
None	--	Positive	--
None	--	Neutral	--
500 mg daily	--	Positive	--
None	--	Positive	--
None	--	Positive	--
None	--	Mixed	--
75 mg	14 weeks	Positive	129
None	--	Mixed	--

Mejor momento para tomar: With meals; bioavailability enhanced by piperine co-supplementation

Safety & Side Effects

Efectos secundarios reportados

⚠ Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses
⚠ Headache
⚠ May have estrogenic activity at high doses

Interacciones conocidas

● Anticoagulants (may inhibit platelet aggregation)
● CYP450 substrates (may inhibit CYP1A2, CYP3A4, CYP2D6)
● Blood pressure medications (additive hypotensive effect)
● Estrogen-sensitive conditions (weak estrogenic activity)

Ingesta máxima tolerable: Not formally established; GI discomfort common above 1,000 mg/day

Consulte siempre a su profesional de salud antes de comenzar cualquier suplemento.Siempre consulte a su profesional de salud antes de comenzar cualquier suplemento.

Frequently Asked Questions

Does Resveratrol help with High Blood Pressure (Hypertension)?

Based on 10 studies with 600 participants, there is moderate evidence from clinical studies that Resveratrol may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).

How much Resveratrol should I take for High Blood Pressure (Hypertension)?

Studies have used various dosages. A commonly studied range is 150-500 mg/day. Always consult your healthcare provider before starting any supplement regimen.

Are there side effects of Resveratrol?

Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses, Headache, May have estrogenic activity at high doses. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.

How strong is the evidence for Resveratrol and High Blood Pressure (Hypertension)?

We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 600 total participants. The overall direction of effect is positive.

Otros ingredientes para High Blood Pressure (Hypertension)

Beetroot Extract A Garlic A Magnesium B Potassium B Quercetin B Grape Seed Extract B

Resveratrol para otras condiciones

Atherosclerosis C

Veredicto rápido

Meta-analysis: systolic -11.9 mmHg in hypertensives at >=150 mg/day. Improved flow-mediated dilation in multiple RCTs. Bioavailability limitations noted.

Evidence Strength72%

High confidence

Desglose de estudios

RCT (0)Meta (0)Other (10)

Comparar alternativas

Vea cómo se comparan otros ingredientes para esta condición.

Ver todos los ingredientes para High Blood Pressure (Hypertension)

Más información

References

[1] Zhuyubing Fang et al.. ESC Heart Fail. 2025. Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues. doi:10.1002/ehf2.14947 PubMed
[2] Hygerta Berisha et al.. Nutrients. 2025. Nutrition and Lifestyle Interventions in Managing Dyslipidemia and Cardiometabolic Risk. doi:10.3390/nu17050776 PubMed
[3] Takafumi Ushida et al.. Hypertens Res. 2025. Dietary supplements and prevention of preeclampsia. doi:10.1038/s41440-025-02144-9 PubMed
[4] Ali Amini et al.. Cardiovasc Hematol Disord Drug Targets. 2025. The Effects of Resveratrol on Menopausal Cardio-metabolic Changes: A Systematic Review. doi:10.2174/011871529X398468250910225946 PubMed
[5] Tao Jin et al.. Acta Biochim Pol. 2022. Resveratrol inhibits cerebral aneurysms in mice via downregulating the NF-κB pathway. doi:10.18388/abp.2020_5982 PubMed
[6] Laura M Mongioì et al.. Int J Mol Sci. 2021. The Role of Resveratrol Administration in Human Obesity. doi:10.3390/ijms22094362 PubMed
[7] Jay Jay Thaung Zaw et al.. Nutrients. 2020. Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women. doi:10.3390/nu12030828 PubMed
[8] Raúl Francisco Pastor et al.. Nutrients. 2020. Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome. doi:10.3390/nu12103149 PubMed
[9] Ligia J Dominguez et al.. Acta Biomed. 2018. Nutritional prevention of cognitive decline and dementia. doi:10.23750/abm.v89i2.7401 PubMed

Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.

Resveratrol para High Blood Pressure (Hypertension)

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Conclusión

Key Study Findings

Key Statistics

Referenced Papers

Dosage & Usage

Dosificaciones de uso común

Dosificaciones estudiadas en la investigación

Safety & Side Effects

Efectos secundarios reportados

Interacciones conocidas

Frequently Asked Questions

Related Evidence

Otros ingredientes para High Blood Pressure (Hypertension)

Resveratrol para otras condiciones

References