What is the recommended dosage for Resveratrol?

General: 150-500 mg/day; Cardiovascular Support: 250-500 mg/day trans-resveratrol

What are the side effects of Resveratrol?

Potential side effects include: Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses, Headache, May have estrogenic activity at high doses.

What is resveratrol and how may it support cardiovascular health?

Resveratrol is a polyphenol found in red grape skins, red wine, and Japanese knotweed. It has shown cardioprotective effects in laboratory studies through antioxidant, anti-inflammatory, and endothelial-protective mechanisms. Human clinical trials show some benefits for blood pressure and lipid profiles, but evidence for cardiovascular event reduction is lacking.

What dosage of resveratrol has been studied for cardiovascular health?

Clinical studies have used 75–500 mg of resveratrol per day. A meta-analysis found blood pressure benefits at doses above 150 mg daily. Bioavailability is a challenge, as resveratrol undergoes extensive first-pass metabolism. Trans-resveratrol is the more bioactive isomer. Study durations ranged from 4 to 24 weeks.

What are the potential side effects of resveratrol?

Common side effects include gastrointestinal discomfort, nausea, and diarrhea at higher doses. Resveratrol may have estrogenic activity and should be used cautiously with hormone-sensitive conditions. It may interact with blood thinners, NSAIDs, and drugs metabolized by CYP enzymes. No serious adverse events have been reported in clinical trials.

Resveratrol
Resveratrol

antioxidant

También conocido como: trans-Resveratrol, 3,5,4'-Trihydroxystilbene, Red Wine Polyphenol

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About

Resveratrol is a polyphenolic stilbene that activates SIRT1 and AMPK pathways, enhances endothelial nitric oxide production, and inhibits LDL oxidation. A 2015 meta-analysis of 10 RCTs found resveratrol at >=150 mg/day reduced systolic blood pressure by 11.9 mmHg in hypertensive patients. Bioavailability remains a challenge due to rapid hepatic metabolism.

How It Works

Activates SIRT1 and AMPK pathways enhancing mitochondrial biogenesis; potent inhibitor of LDL oxidation and foam cell formation; enhances endothelial nitric oxide synthase (eNOS) expression improving vasodilation; inhibits platelet aggregation through COX-1 and thromboxane A2 pathways; anti-inflammatory via NF-kB suppression.

Evidence For Conditions

Condición	Calificación	Estudios	Participantes
High Blood Pressure (Hypertension)	B	10	600	Ver →
Atherosclerosis	C	5	400	Ver →

Side Effects

Gastrointestinal discomfort (nausea, diarrhea, cramping) at high doses
Headache
May have estrogenic activity at high doses

Drug & Supplement Interactions

Anticoagulants (may inhibit platelet aggregation)
CYP450 substrates (may inhibit CYP1A2, CYP3A4, CYP2D6)
Blood pressure medications (additive hypotensive effect)
Estrogen-sensitive conditions (weak estrogenic activity)

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Grape Seed Extract Astaxanthin Quercetin Lycopene

Datos rápidos

Dosificación: General: 150-500 mg/day; Cardiovascular_Support: 250-500 mg/day trans-resveratrol
Formas: capsule tablet liquid powder
Fuentes naturales: Red grape skins, Red wine, Peanuts, Japanese knotweed (Polygonum cuspidatum), Blueberries, Dark chocolate
Límite superior: Not formally established; GI discomfort common above 1,000 mg/day
Mejor momento: With meals; bioavailability enhanced by piperine co-supplementation

Resumen de evidencia

High Blood Pressure (Hypertension) B

Atherosclerosis C

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Aviso legal FDA: Estas declaraciones no han sido evaluadas por la Food and Drug Administration. Los productos y la información en este sitio web no están destinados a diagnosticar, tratar, curar ni prevenir ninguna enfermedad. Las calificaciones de evidencia presentadas se basan en nuestro análisis de investigación publicada revisada por pares y no constituyen consejo médico. Siempre consulte a su profesional de salud antes de comenzar cualquier régimen de suplementos.