Quercetin für High Blood Pressure (Hypertension)
B Evidenz Mindestens eine randomisierte Studie unterstützt dies, mit überwiegend konsistenten Ergebnissen.Meta-analysis of 17 RCTs: systolic -3.09 mmHg at >=500 mg/day. More effective in >=8-week studies and hypertensive subjects. Phytosome form preferred for bioavailability.
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B
Fazit
Meta-analysis of 17 RCTs: systolic -3.09 mmHg at >=500 mg/day. More effective in >=8-week studies and hypertensive subjects. Phytosome form preferred for bioavailability.
Key Study Findings
In Vitro
Kyoh® Rocket Leaf Extract Regulates Proliferation and VEGF and FGF7 Expression in Human Dermal Follicle …
Dose: None
vs.: Untreated dermal follicle papilla cells
Outcome: VEGF and FGF7 gene expression
Wirkung: VEGF +267.3%, FGF7 +244.3% at 24h
None
Population: Human dermal follicle papilla cells (in vitro)
Review
Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review.
Dose: None
vs.: None
Outcome: None
Wirkung: None
None
Population: None
Review
Effects of plant-derived dietary antioxidants on Alzheimer's disease: Focus on ferroptosis.
Dose: None
vs.: None
Outcome: Cognitive decline via ferroptosis regulation in AD
Wirkung: None
None
Population: AD patients and healthy elderly
Review
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
Dose: None
vs.: None
Outcome: None
Wirkung: None
None
Population: review of plant-derived anti-inflammatory compounds for chronic disease prevention
Other
Exploration of Potential Targets and Molecular Mechanisms of the Yiqi Jianpi Tongqiao Formula in Treating …
Dose: None
vs.: Allergic rhinitis mouse model vs control
Outcome: Rhinitis symptoms and serum inflammatory indicators
Wirkung: None
None
Population: Allergic rhinitis mouse model
Review
The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications.
Dose: None
vs.: None
Outcome: None
Wirkung: None
None
Population: Review of flavonoids/phenolics in diabetic macrovascular
Key Statistics
17
Studien
900
Teilnehmer
↑
Positive
B
Bewertung
Referenced Papers
International journal of …
2025
32 Zitierungen
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 Zitierungen
Nutrients
2025
9 Zitierungen
Journal of ethnopharmacology
2025
5 Zitierungen
Biology
2025
3 Zitierungen
Current computer-aided drug …
2025
2 Zitierungen
Asia Pacific journal …
2025
1 Zitierungen
Phytotherapy research : …
2025
1 Zitierungen
Molecules (Basel, Switzerland)
2025
Iranian journal of …
2024
4 Zitierungen
Indian journal of …
2024
2 Zitierungen
Voprosy pitaniia
2023
19 Zitierungen
Cells
2023
13 Zitierungen
Nutrition research (New …
2022
75 Zitierungen
International journal of …
2022
23 Zitierungen
Evidence-based complementary and …
2022
7 Zitierungen
International journal of …
2021
20 Zitierungen
Medicines (Basel, Switzerland)
2021
16 Zitierungen
Biomedicine & pharmacotherapy …
2020
427 Zitierungen
Pharmacological research
2019
31 Zitierungen
Oxidative medicine and …
2017
87 Zitierungen
Integrative medicine insights
2015
100 Zitierungen
International journal of …
2006
92 Zitierungen
Current drug targets
2006
92 Zitierungen
Journal of medicinal …
2002
135 Zitierungen
Alternative medicine review …
2000
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Übliche Dosierungen
- general:
- 500-1,000 mg/day
- bloodpressuresupport:
- 500-730 mg/day
Obergrenze: Not formally established; up to 1,000 mg/day used in clinical trials
In der Forschung untersuchte Dosierungen
| Dosierung | Dauer | Wirkung | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
Beste Einnahmezeit: With meals; vitamin C co-supplementation may enhance bioavailability
Safety & Side Effects
Gemeldete Nebenwirkungen
- ⚠ Generally well-tolerated
- ⚠ Headache (rare)
- ⚠ Mild gastrointestinal discomfort
- ⚠ Tingling in extremities (rare, high doses)
Bekannte Wechselwirkungen
- ● Antibiotics (quinolones — may reduce efficacy)
- ● Cyclosporine (may increase blood levels)
- ● Anticoagulants (may have mild antiplatelet effect)
- ● Blood pressure medications (additive effect)
Tolerierbare Höchstaufnahmemenge: Not formally established; up to 1,000 mg/day used in clinical trials
Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.Konsultieren Sie immer Ihren Arzt, bevor Sie ein Nahrungsergänzungsmittel einnehmen.
Frequently Asked Questions
Does Quercetin help with High Blood Pressure (Hypertension)?
Based on 17 studies with 900 participants, there is moderate evidence from clinical studies that Quercetin may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).
How much Quercetin should I take for High Blood Pressure (Hypertension)?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Quercetin?
Reported side effects may include Generally well-tolerated, Headache (rare), Mild gastrointestinal discomfort, Tingling in extremities (rare, high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Quercetin and High Blood Pressure (Hypertension)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 17 peer-reviewed studies with 900 total participants. The overall direction of effect is positive.
Related Evidence
Andere Inhaltsstoffe für High Blood Pressure (Hypertension)
Quercetin für andere Beschwerden
References
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- [2] Monika Martiniakova et al.. Nutrients. 2025. Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus. doi:10.3390/nu17020275 PubMed
- [3] Matteo Naso et al.. Nutrients. 2025. Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review. doi:10.3390/nu17091476 PubMed
- [4] Xing-Yuan Li et al.. J Ethnopharmacol. 2025. Inhibition of mitochondrial oxidative stress and apoptosis in the protection of Ginkgo biloba extract 50 against cognitive impairment. doi:10.1016/j.jep.2025.120059 PubMed
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- [7] Feng Gu et al.. Asia Pac J Clin Nutr. 2025. Effects of plant-derived dietary antioxidants on Alzheimer's disease: Focus on ferroptosis. doi:10.6133/apjcn.202512_34(6).0007 PubMed
- [8] Aminu Mohammed et al.. Phytother Res. 2025. The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications. doi:10.1002/ptr.70070 PubMed
- [9] Adal Mena-García et al.. Molecules. 2025. Kyoh® Rocket Leaf Extract Regulates Proliferation and VEGF and FGF7 Expression in Human Dermal Follicle Papilla Cells. doi:10.3390/molecules30071489 PubMed
- [10] Masoumeh Shamsi et al.. Iran J Pharm Res. 2024. Dual Modulation of Canonical and Non-canonical TGF-β/ROS/Erk1/2 Pathways: Synergistic Activation of Nrf-2 and Antioxidant Enzymes (SOD1, GPx, HO-1) by Quercetin … doi:10.5812/ijpr-151428 PubMed
- [11] Devi Datt Joshi et al.. Indian J Microbiol. 2024. Relevance of Indian Traditional Herbal Brews for Gut Microbiota Balance. doi:10.1007/s12088-024-01251-4 PubMed
- [12] T N Bobrysheva et al.. Vopr Pitan. 2023. [Polyphenols as promising bioactive compounds]. doi:10.33029/0042-8833-2023-92-1-92-107 PubMed
- [13] Sina Kaag et al.. Cells. 2023. Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies? doi:10.3390/cells12222602 PubMed
- [14] Karen S Coutinho-Wolino et al.. Nutr Res. 2022. Bioactive compounds modulating Toll-like 4 receptor (TLR4)-mediated inflammation: pathways involved and future perspectives. doi:10.1016/j.nutres.2022.09.001 PubMed
- [15] Alzbeta Katonova et al.. Int J Mol Sci. 2022. Effect of a Vegan Diet on Alzheimer's Disease. doi:10.3390/ijms232314924 PubMed
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- [17] Pamela Senesi et al.. Int J Mol Sci. 2021. Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction. doi:10.3390/ijms22157772 PubMed
- [18] Takayuki Okumo et al.. Medicines (Basel). 2021. Inhibition of Angiogenic Factor Productions by Quercetin In Vitro and In Vivo. doi:10.3390/medicines8050022 PubMed
- [19] Gang Gong et al.. Biomed Pharmacother. 2020. Isorhamnetin: A review of pharmacological effects. doi:10.1016/j.biopha.2020.110301 PubMed
- [20] Wang Anlu et al.. Pharmacol Res. 2019. Using herbal medicine to target the "microbiota-metabolism-immunity" axis as possible therapy for cardiovascular disease. doi:10.1016/j.phrs.2019.02.018 PubMed
- [21] A Tressera-Rimbau et al.. Oxid Med Cell Longev. 2017. Dietary Polyphenols in the Prevention of Stroke. doi:10.1155/2017/7467962 PubMed
- [22] Kevin M Nash et al.. Integr Med Insights. 2015. Current Perspectives on the Beneficial Role of Ginkgo biloba in Neurological and Cerebrovascular Disorders. doi:10.4137/IMI.S25054 PubMed
- [23] Irfan Rahman. Int J Chron Obstruct Pulmon Dis. 2006. Antioxidant therapies in COPD. doi:10.2147/copd.2006.1.1.15 PubMed
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- [25] Amanpreet Singh et al.. J Med Food. 2002. Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. doi:10.1089/109662002763003366 PubMed
- [26] S M Thornhill et al.. Altern Med Rev. 2000. Natural treatment of perennial allergic rhinitis. PubMed
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