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HeartCited

Red Yeast Rice
Red Yeast Rice

herb

别名: Monascus purpureus, Monacolin K, Xuezhikang, Hong Qu, Cholestin

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About





            

                
Red yeast rice contains monacolin K, chemically identical to lovastatin, which inhibits HMG-CoA reductase. The CCSPS trial (4,870 post-MI patients) demonstrated Xuezhikang reduced recurrent MI by 45% and total mortality by 33%. However, the FDA has taken enforcement action against high-monacolin K products, and product quality varies enormously — citrinin contamination is a significant concern.

            

        

        

        
        
        

            

  
How It Works





            

                
Contains monacolin K — chemically identical to lovastatin — which inhibits HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis; additional monacolins and phytosterols may provide cholesterol-lowering effects beyond monacolin K alone; isoflavones and sterols provide antioxidant and anti-inflammatory properties.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                健康状况
                                等级
                                研究数量
                                受试者
                                
                            

                        
                        
                            
                            

                                
                                    
                                        High Cholesterol (Hyperlipidemia)
                                    
                                
                                
                                    A

                                
                                
                                    22
                                
                                
                                    8000
                                
                                
                                    
                                        查看 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Myalgia (muscle pain — same mechanism as statins)
                
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                    Gastrointestinal discomfort
                
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                    Elevated liver enzymes (rare)
                
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                    Citrinin contamination risk in poorly manufactured products
                
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                    Rhabdomyolysis (rare, at high doses)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Statins (contraindicated — same mechanism, additive myopathy risk)
                
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                    CYP3A4 inhibitors (grapefruit juice, certain antibiotics — increased monacolin K levels)
                
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                    Fibrates (increased myopathy risk)
                
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                    Cyclosporine (increased myopathy risk)
                
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                    Niacin (increased myopathy risk at high doses)
                
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                请务必告知您的医疗保健提供者您正在服用的所有补充剂。
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Hawthorn
                    
                
                
                
                    Garlic
                    
                
                
                
                    Curcumin
                    
                
                
                
                    Berberine
                    
                
                
            

        

        
    


    
    












    

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