Quercetin para High Blood Pressure (Hypertension)
B Evidências Pelo menos um ensaio aleatorizado apoia esta conclusão, com resultados maioritariamente consistentes.Meta-analysis of 17 RCTs: systolic -3.09 mmHg at >=500 mg/day. More effective in >=8-week studies and hypertensive subjects. Phytosome form preferred for bioavailability.
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B
Conclusão
Meta-analysis of 17 RCTs: systolic -3.09 mmHg at >=500 mg/day. More effective in >=8-week studies and hypertensive subjects. Phytosome form preferred for bioavailability.
Key Study Findings
In Vitro
Kyoh® Rocket Leaf Extract Regulates Proliferation and VEGF and FGF7 Expression in Human Dermal Follicle …
Dose: None
vs: Untreated dermal follicle papilla cells
Outcome: VEGF and FGF7 gene expression
Efeito: VEGF +267.3%, FGF7 +244.3% at 24h
None
População: Human dermal follicle papilla cells (in vitro)
Review
Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review.
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: None
Review
Effects of plant-derived dietary antioxidants on Alzheimer's disease: Focus on ferroptosis.
Dose: None
vs: None
Outcome: Cognitive decline via ferroptosis regulation in AD
Efeito: None
None
População: AD patients and healthy elderly
Review
Anti-Inflammatory Actions of Plant-Derived Compounds and Prevention of Chronic Diseases: From Molecular Mechanisms to Applications.
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: review of plant-derived anti-inflammatory compounds for chronic disease prevention
Other
Exploration of Potential Targets and Molecular Mechanisms of the Yiqi Jianpi Tongqiao Formula in Treating …
Dose: None
vs: Allergic rhinitis mouse model vs control
Outcome: Rhinitis symptoms and serum inflammatory indicators
Efeito: None
None
População: Allergic rhinitis mouse model
Review
The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications.
Dose: None
vs: None
Outcome: None
Efeito: None
None
População: Review of flavonoids/phenolics in diabetic macrovascular
Key Statistics
17
Estudos
900
Participantes
↑
Positive
B
Nota
Referenced Papers
International journal of …
2025
32 citações
Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus.
Review
Nutrients
2025
32 citações
Nutrients
2025
9 citações
Journal of ethnopharmacology
2025
5 citações
Biology
2025
3 citações
Current computer-aided drug …
2025
2 citações
Asia Pacific journal …
2025
1 citações
Phytotherapy research : …
2025
1 citações
Molecules (Basel, Switzerland)
2025
Iranian journal of …
2024
4 citações
Indian journal of …
2024
2 citações
Voprosy pitaniia
2023
19 citações
Cells
2023
13 citações
Nutrition research (New …
2022
75 citações
International journal of …
2022
23 citações
Evidence-based complementary and …
2022
7 citações
International journal of …
2021
20 citações
Medicines (Basel, Switzerland)
2021
16 citações
Biomedicine & pharmacotherapy …
2020
427 citações
Pharmacological research
2019
31 citações
Oxidative medicine and …
2017
87 citações
Integrative medicine insights
2015
100 citações
International journal of …
2006
92 citações
Current drug targets
2006
92 citações
Journal of medicinal …
2002
135 citações
Alternative medicine review …
2000
Dosage & Usage
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units
Dosagens Comumente Utilizadas
- general:
- 500-1,000 mg/day
- bloodpressuresupport:
- 500-730 mg/day
Limite superior: Not formally established; up to 1,000 mg/day used in clinical trials
Dosagens Estudadas em Pesquisas
| Dosagem | Duração | Efeito | N |
|---|---|---|---|
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
| None | -- | Mixed | -- |
| None | -- | Positive | -- |
| None | -- | Positive | -- |
Melhor horário: With meals; vitamin C co-supplementation may enhance bioavailability
Safety & Side Effects
Efeitos Colaterais Relatados
- ⚠ Generally well-tolerated
- ⚠ Headache (rare)
- ⚠ Mild gastrointestinal discomfort
- ⚠ Tingling in extremities (rare, high doses)
Interações Conhecidas
- ● Antibiotics (quinolones — may reduce efficacy)
- ● Cyclosporine (may increase blood levels)
- ● Anticoagulants (may have mild antiplatelet effect)
- ● Blood pressure medications (additive effect)
Ingestão máxima tolerável: Not formally established; up to 1,000 mg/day used in clinical trials
Consulte sempre o seu profissional de saúde antes de iniciar qualquer suplemento.Sempre consulte seu profissional de saúde antes de iniciar qualquer suplemento.
Frequently Asked Questions
Does Quercetin help with High Blood Pressure (Hypertension)?
Based on 17 studies with 900 participants, there is moderate evidence from clinical studies that Quercetin may support High Blood Pressure (Hypertension) management. Our evidence grade is B (Good Evidence).
How much Quercetin should I take for High Blood Pressure (Hypertension)?
Studies have used various dosages. A commonly studied range is 500-1,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
Are there side effects of Quercetin?
Reported side effects may include Generally well-tolerated, Headache (rare), Mild gastrointestinal discomfort, Tingling in extremities (rare, high doses). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
How strong is the evidence for Quercetin and High Blood Pressure (Hypertension)?
We rate the evidence as Grade B (Good Evidence). This rating is based on 17 peer-reviewed studies with 900 total participants. The overall direction of effect is positive.
Related Evidence
Outros ingredientes para High Blood Pressure (Hypertension)
Quercetin para outras condições
References
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- [2] Monika Martiniakova et al.. Nutrients. 2025. Protective Role of Dietary Polyphenols in the Management and Treatment of Type 2 Diabetes Mellitus. doi:10.3390/nu17020275 PubMed
- [3] Matteo Naso et al.. Nutrients. 2025. Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review. doi:10.3390/nu17091476 PubMed
- [4] Xing-Yuan Li et al.. J Ethnopharmacol. 2025. Inhibition of mitochondrial oxidative stress and apoptosis in the protection of Ginkgo biloba extract 50 against cognitive impairment. doi:10.1016/j.jep.2025.120059 PubMed
- [5] Ki-Yeon Yoo et al.. Biology (Basel). 2025. Therapeutic Potential of Natural Compounds for Brain Ischemia-Reperfusion Injury. doi:10.3390/biology14091153 PubMed
- [6] Sihong Huang et al.. Curr Comput Aided Drug Des. 2025. Exploration of Potential Targets and Molecular Mechanisms of the Yiqi Jianpi Tongqiao Formula in Treating Allergic Rhinitis Mouse Model based … doi:10.2174/0115734099299714240516160158 PubMed
- [7] Feng Gu et al.. Asia Pac J Clin Nutr. 2025. Effects of plant-derived dietary antioxidants on Alzheimer's disease: Focus on ferroptosis. doi:10.6133/apjcn.202512_34(6).0007 PubMed
- [8] Aminu Mohammed et al.. Phytother Res. 2025. The Roles of Flavonoids and Other Plant-Based Phenolics in Mitigating Diabetes-Induced Macrovascular Complications. doi:10.1002/ptr.70070 PubMed
- [9] Adal Mena-García et al.. Molecules. 2025. Kyoh® Rocket Leaf Extract Regulates Proliferation and VEGF and FGF7 Expression in Human Dermal Follicle Papilla Cells. doi:10.3390/molecules30071489 PubMed
- [10] Masoumeh Shamsi et al.. Iran J Pharm Res. 2024. Dual Modulation of Canonical and Non-canonical TGF-β/ROS/Erk1/2 Pathways: Synergistic Activation of Nrf-2 and Antioxidant Enzymes (SOD1, GPx, HO-1) by Quercetin … doi:10.5812/ijpr-151428 PubMed
- [11] Devi Datt Joshi et al.. Indian J Microbiol. 2024. Relevance of Indian Traditional Herbal Brews for Gut Microbiota Balance. doi:10.1007/s12088-024-01251-4 PubMed
- [12] T N Bobrysheva et al.. Vopr Pitan. 2023. [Polyphenols as promising bioactive compounds]. doi:10.33029/0042-8833-2023-92-1-92-107 PubMed
- [13] Sina Kaag et al.. Cells. 2023. Effects of Dietary Components on Mast Cells: Possible Use as Nutraceuticals for Allergies? doi:10.3390/cells12222602 PubMed
- [14] Karen S Coutinho-Wolino et al.. Nutr Res. 2022. Bioactive compounds modulating Toll-like 4 receptor (TLR4)-mediated inflammation: pathways involved and future perspectives. doi:10.1016/j.nutres.2022.09.001 PubMed
- [15] Alzbeta Katonova et al.. Int J Mol Sci. 2022. Effect of a Vegan Diet on Alzheimer's Disease. doi:10.3390/ijms232314924 PubMed
- [16] Minye Qu et al.. Evid Based Complement Alternat Med. 2022. Network Pharmacology and Molecular Docking Study of Yupingfeng Powder in the Treatment of Allergic Diseases. doi:10.1155/2022/1323744 PubMed
- [17] Pamela Senesi et al.. Int J Mol Sci. 2021. Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction. doi:10.3390/ijms22157772 PubMed
- [18] Takayuki Okumo et al.. Medicines (Basel). 2021. Inhibition of Angiogenic Factor Productions by Quercetin In Vitro and In Vivo. doi:10.3390/medicines8050022 PubMed
- [19] Gang Gong et al.. Biomed Pharmacother. 2020. Isorhamnetin: A review of pharmacological effects. doi:10.1016/j.biopha.2020.110301 PubMed
- [20] Wang Anlu et al.. Pharmacol Res. 2019. Using herbal medicine to target the "microbiota-metabolism-immunity" axis as possible therapy for cardiovascular disease. doi:10.1016/j.phrs.2019.02.018 PubMed
- [21] A Tressera-Rimbau et al.. Oxid Med Cell Longev. 2017. Dietary Polyphenols in the Prevention of Stroke. doi:10.1155/2017/7467962 PubMed
- [22] Kevin M Nash et al.. Integr Med Insights. 2015. Current Perspectives on the Beneficial Role of Ginkgo biloba in Neurological and Cerebrovascular Disorders. doi:10.4137/IMI.S25054 PubMed
- [23] Irfan Rahman. Int J Chron Obstruct Pulmon Dis. 2006. Antioxidant therapies in COPD. doi:10.2147/copd.2006.1.1.15 PubMed
- [24] Irfan Rahman et al.. Curr Drug Targets. 2006. Antioxidant therapeutic targets in COPD. doi:10.2174/138945006777435254 PubMed
- [25] Amanpreet Singh et al.. J Med Food. 2002. Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. doi:10.1089/109662002763003366 PubMed
- [26] S M Thornhill et al.. Altern Med Rev. 2000. Natural treatment of perennial allergic rhinitis. PubMed
Aviso Legal da FDA: Estas declarações não foram avaliadas pela Food and Drug Administration. Os produtos e informações neste site não se destinam a diagnosticar, tratar, curar ou prevenir qualquer doença. As notas de evidência apresentadas são baseadas em nossa análise de pesquisas revisadas por pares publicadas e não constituem aconselhamento médico. Sempre consulte seu profissional de saúde antes de iniciar qualquer regime de suplementação.