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HeartCited

Garlic
Garlic

herb

別名: Aged Garlic Extract (AGE), Kyolic, Allium sativum, Allicin, S-Allylcysteine

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About





            

                
Garlic, particularly aged garlic extract (AGE), has extensive evidence for blood pressure reduction. A 2020 meta-analysis of 12 RCTs found garlic reduced systolic blood pressure by 8.3 mmHg — comparable to first-line antihypertensives. The AGE at Heart trial showed 2,400 mg/day AGE reduced coronary artery calcium progression by 80% in 65 firefighters over 1 year.

            

        

        

        
        
        

            

  
How It Works





            

                
Allicin and S-allylcysteine (SAC) in aged garlic extract inhibit HMG-CoA reductase and cholesterol synthesis; enhance hydrogen sulfide (H2S) production promoting vasodilation; inhibit ACE and calcium channel activity reducing blood pressure; polysulfides activate TRPA1 channels on sensory nerves causing vasorelaxation; reduce platelet aggregation; antioxidant effects reduce ox-LDL formation.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                症状・状態
                                グレード
                                研究数
                                参加者数
                                
                            

                        
                        
                            
                            

                                
                                    
                                        High Blood Pressure (Hypertension)
                                    
                                
                                
                                    A

                                
                                
                                    12
                                
                                
                                    550
                                
                                
                                    
                                        詳細を見る →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Body odor and bad breath (less with AGE)
                
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                    Gastrointestinal discomfort (heartburn, nausea, gas)
                
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                    Increased bleeding risk
                
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                    Allergic reactions (rare)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Anticoagulants (increased bleeding risk — discontinue 7 days before surgery)
                
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                    Antiplatelet drugs (additive antiplatelet effect)
                
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                    HIV protease inhibitors (saquinavir — reduced levels)
                
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                    CYP3A4 substrates (may alter metabolism)
                
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                    Blood pressure medications (additive hypotensive effect)
                
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Related Ingredients





            

                
                
                    Hawthorn
                    
                
                
                
                    Curcumin
                    
                
                
                
                    Berberine
                    
                
                
                
                    Red Yeast Rice
                    
                
                
            

        

        
    


    
    












    

        FDAに関する免責事項:
        これらの記述は米国食品医薬品局（FDA）による評価を受けていません。本ウェブサイトの製品および情報は、疾病の診断、治療、治癒、または予防を目的としたものではありません。表示されているエビデンスグレードは、公開された査読済み研究の分析に基づいており、医療上の助言を構成するものではありません。サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。