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HeartCited

Garlic
Garlic

herb

다른 이름: Aged Garlic Extract (AGE), Kyolic, Allium sativum, Allicin, S-Allylcysteine

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About





            

                
Garlic, particularly aged garlic extract (AGE), has extensive evidence for blood pressure reduction. A 2020 meta-analysis of 12 RCTs found garlic reduced systolic blood pressure by 8.3 mmHg — comparable to first-line antihypertensives. The AGE at Heart trial showed 2,400 mg/day AGE reduced coronary artery calcium progression by 80% in 65 firefighters over 1 year.

            

        

        

        
        
        

            

  
How It Works





            

                
Allicin and S-allylcysteine (SAC) in aged garlic extract inhibit HMG-CoA reductase and cholesterol synthesis; enhance hydrogen sulfide (H2S) production promoting vasodilation; inhibit ACE and calcium channel activity reducing blood pressure; polysulfides activate TRPA1 channels on sensory nerves causing vasorelaxation; reduce platelet aggregation; antioxidant effects reduce ox-LDL formation.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                건강 상태
                                등급
                                연구
                                참여자
                                
                            

                        
                        
                            
                            

                                
                                    
                                        High Blood Pressure (Hypertension)
                                    
                                
                                
                                    A

                                
                                
                                    12
                                
                                
                                    550
                                
                                
                                    
                                        보기 →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Body odor and bad breath (less with AGE)
                
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                    Gastrointestinal discomfort (heartburn, nausea, gas)
                
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                    Increased bleeding risk
                
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                    Allergic reactions (rare)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Anticoagulants (increased bleeding risk — discontinue 7 days before surgery)
                
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                    Antiplatelet drugs (additive antiplatelet effect)
                
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                    HIV protease inhibitors (saquinavir — reduced levels)
                
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                    CYP3A4 substrates (may alter metabolism)
                
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                    Blood pressure medications (additive hypotensive effect)
                
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                복용 중인 모든 건강기능식품에 대해 반드시 의료 전문가에게 알리십시오.
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Hawthorn
                    
                
                
                
                    Curcumin
                    
                
                
                
                    Berberine
                    
                
                
                
                    Red Yeast Rice
                    
                
                
            

        

        
    


    
    












    

        FDA 면책 조항:
        이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.