What is the recommended dosage for Vitamin D?

General: 600-800 IU/day; Deficiency Correction: 4,000-5,000 IU/day (under medical supervision); Cardiovascular Support: 1,000-2,000 IU/day

What are the side effects of Vitamin D?

Potential side effects include: Hypercalcemia at very high doses (fatigue, nausea, kidney stones), Constipation, Generally very safe at recommended doses.

What is vitamin D and how may it relate to cardiovascular health?

Vitamin D is a fat-soluble vitamin with receptors in heart and vascular tissue. Observational studies consistently link vitamin D deficiency with increased cardiovascular risk. However, large RCTs including VITAL have not demonstrated that vitamin D supplementation reduces cardiovascular events in the general population.

What dosage of vitamin D has been studied for cardiovascular outcomes?

Clinical trials have used 1,000–4,000 IU of vitamin D3 per day for cardiovascular endpoints. The VITAL trial used 2,000 IU daily for over 5 years. Correcting deficiency (25-OH-D below 20 ng/mL) appears more important than supplementing adequate levels. Dosing should be guided by blood testing.

What are the potential side effects of vitamin D supplements?

Vitamin D is generally safe at recommended doses. Excessive intake can cause hypercalcemia, leading to nausea, kidney stones, and cardiac arrhythmias. Vitamin D may interact with certain heart medications including digoxin (hypercalcemia risk) and thiazide diuretics. Blood calcium levels should be monitored at high supplemental doses.

Vitamin D
Vitamin D

vitamin

Aussi connu sous le nom de: Cholecalciferol (D3), Ergocalciferol (D2), Calciferol, Calcidiol

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About

Vitamin D binds to receptors on cardiomyocytes, vascular smooth muscle, and endothelial cells, regulating calcium handling and the renin-angiotensin-aldosterone system. Observational studies show deficiency (<20 ng/mL) is associated with 50-80% increased cardiovascular risk, though the VITAL trial (25,871 participants) found supplementation did not significantly reduce major cardiovascular events.

How It Works

Binds to vitamin D receptors (VDR) on cardiomyocytes, vascular smooth muscle, and endothelial cells regulating calcium handling and contractile function; modulates the renin-angiotensin-aldosterone system (RAAS) — deficiency upregulates renin contributing to hypertension; suppresses vascular inflammation via NF-kB inhibition; supports endothelial nitric oxide synthase (eNOS) expression.

Evidence For Conditions

Pathologie	Note	Études	Participants
High Blood Pressure (Hypertension)	C	20	30000	Voir →
Heart Failure	C	6	3000	Voir →

Side Effects

Hypercalcemia at very high doses (fatigue, nausea, kidney stones)
Constipation
Generally very safe at recommended doses

Drug & Supplement Interactions

Thiazide diuretics (may increase hypercalcemia risk)
Statins (theoretical interaction via CYP enzymes)
Corticosteroids (may reduce vitamin D absorption)
Weight loss medications (may reduce absorption of fat-soluble vitamins)

Informez toujours votre professionnel de santé de tous les compléments alimentaires que vous prenez.Informez toujours votre professionnel de santé de tous les compléments que vous prenez.

Related Ingredients

Vitamin K2 Niacin (Vitamin B3) Folate (Vitamin B9) Vitamin E

En bref

Posologie: General: 600-800 IU/day; Deficiency_Correction: 4,000-5,000 IU/day (under medical supervision); Cardiovascular_Support: 1,000-2,000 IU/day
Formes: capsule softgel liquid drops tablet gummy
Sources naturelles: Sunlight (UVB synthesis), Fatty fish (salmon, mackerel), Egg yolks, Fortified milk, UV-exposed mushrooms
Limite supérieure: 4,000 IU/day (100 mcg)
Meilleur moment: With a meal containing fat for better absorption

Synthèse des preuves

High Blood Pressure (Hypertension) C

Heart Failure C

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.