Skip to main content
HeartCited

Niacin (Vitamin B3) pour High Cholesterol (Hyperlipidemia)

B

Most effective HDL-raising agent (+15-35%). Coronary Drug Project: 27% MI reduction. However, AIM-HIGH and HPS2-THRIVE showed no incremental benefit when added to statins. Best evidence as monotherapy.

<\/script>\n
`; }, get iframeSnippet() { const domain = 'heartcited.com'; const params = 'ingredient\u003Dniacin\u0026condition\u003Dhigh\u002Dcholesterol'; return ``; }, get activeSnippet() { return this.method === 'script' ? this.scriptSnippet : this.iframeSnippet; }, copySnippet() { navigator.clipboard.writeText(this.activeSnippet).then(() => { this.copied = true; setTimeout(() => { this.copied = false; }, 2000); }); } }" @keydown.escape.window="open = false" @click.outside="open = false">

Embed This Widget

Style



      
      
    


    
    

      Widget powered by
      .
      Free, no account required.
    

  




    








    

        

            B

        

        

            
En conclusion

            
            
Most effective HDL-raising agent (+15-35%). Coronary Drug Project: 27% MI reduction. However, AIM-HIGH and HPS2-THRIVE showed no incremental benefit when added to statins. Best evidence as monotherapy.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
10

        
Études

    

    

        
12000

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Note

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Posologies couramment utilisées

                

                    
                    

                        
generalnutrition:

                        
14-16 mg/day

                    

                    
                    

                        
lipidmodification:

                        
1,000-2,000 mg/day (start at 500 mg/day and titrate)

                    

                    
                

                
                

                    Limite supérieure : 35 mg/day for non-prescription use; prescription doses up to 3,000 mg/day under medical supervi
                

                
            

            

            

            
            

                Moment optimal de prise : With dinner or at bedtime with a low-fat snack; aspirin 30 min before may reduce flushing
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Effets indésirables signalés

                    
    
                        
                        
  • 
                            ⚠
                            Flushing (redness, warmth, itching — most common, especially immediate-release)
                        
    • 
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort (nausea, diarrhea)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hepatotoxicity (especially extended-release at high doses)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hyperglycemia (may worsen blood sugar control)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hyperuricemia (may precipitate gout)
                        
    • 
                        
                    

                

                

                
                

                    
Interactions connues

                    
    
                        
                        
  • 
                            ●
                            Statins (increased risk of myopathy/rhabdomyolysis)
                        
    • 
                        
                        
  • 
                            ●
                            Blood pressure medications (additive hypotensive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Diabetes medications (may counteract blood sugar control)
                        
    • 
                        
                        
  • 
                            ●
                            Anticoagulants (may increase bleeding risk)
                        
    • 
                        
                        
  • 
                            ●
                            Alcohol (may worsen flushing and hepatotoxicity)
                        
    • 
                        
                    

                

                

                
                

                    

                        Apport maximal tolérable : 35 mg/day for non-prescription use; prescription doses up to 3,000 mg/day under medical supervi
                    

                

                
            

            

                Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.Consultez toujours votre professionnel de santé avant de commencer tout complément alimentaire.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Niacin (Vitamin B3) help with High Cholesterol (Hyperlipidemia)?
            
        
        

            Based on 10 studies with 12,000 participants, there is moderate evidence from clinical studies that Niacin (Vitamin B3) may support High Cholesterol (Hyperlipidemia) management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Niacin (Vitamin B3) should I take for High Cholesterol (Hyperlipidemia)?
            
        
        

            Studies have used various dosages. A commonly studied range is 14-16 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Niacin (Vitamin B3)?
            
        
        

            Reported side effects may include Flushing (redness, warmth, itching — most common, especially immediate-release), Gastrointestinal discomfort (nausea, diarrhea), Hepatotoxicity (especially extended-release at high doses), Hyperglycemia (may worsen blood sugar control). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Niacin (Vitamin B3) and High Cholesterol (Hyperlipidemia)?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 10 peer-reviewed studies with 12,000 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
                

                    
Niacin (Vitamin B3) pour d'autres pathologies

                    

                        
                        
                            High Triglycerides (Hypertriglyceridemia)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    












    

        Avertissement FDA:
        Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.