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Garlic
Garlic

herb

يُعرف أيضاً بـ: Aged Garlic Extract (AGE), Kyolic, Allium sativum, Allicin, S-Allylcysteine

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About





            

                
Garlic, particularly aged garlic extract (AGE), has extensive evidence for blood pressure reduction. A 2020 meta-analysis of 12 RCTs found garlic reduced systolic blood pressure by 8.3 mmHg — comparable to first-line antihypertensives. The AGE at Heart trial showed 2,400 mg/day AGE reduced coronary artery calcium progression by 80% in 65 firefighters over 1 year.

            

        

        

        
        
        

            

  
How It Works





            

                
Allicin and S-allylcysteine (SAC) in aged garlic extract inhibit HMG-CoA reductase and cholesterol synthesis; enhance hydrogen sulfide (H2S) production promoting vasodilation; inhibit ACE and calcium channel activity reducing blood pressure; polysulfides activate TRPA1 channels on sensory nerves causing vasorelaxation; reduce platelet aggregation; antioxidant effects reduce ox-LDL formation.

            

        

        

        
        
        

            

  
Evidence For Conditions





            

                

                    

                        
                            

                                الحالة
                                التقييم
                                الدراسات
                                المشاركون
                                
                            

                        
                        
                            
                            

                                
                                    
                                        High Blood Pressure (Hypertension)
                                    
                                
                                
                                    A

                                
                                
                                    12
                                
                                
                                    550
                                
                                
                                    
                                        عرض →
                                    
                                
                            

                            
                        
                    

                

            

        

        

        
        
        

            

  
Side Effects





            
    
                
                
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                    Body odor and bad breath (less with AGE)
                
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                    Gastrointestinal discomfort (heartburn, nausea, gas)
                
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                    Increased bleeding risk
                
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                    Allergic reactions (rare)
                
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Drug & Supplement Interactions





            
    
                
                
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                    Anticoagulants (increased bleeding risk — discontinue 7 days before surgery)
                
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                    Antiplatelet drugs (additive antiplatelet effect)
                
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                    HIV protease inhibitors (saquinavir — reduced levels)
                
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                    CYP3A4 substrates (may alter metabolism)
                
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                    Blood pressure medications (additive hypotensive effect)
                
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                أخبر مقدم الرعاية الصحية دائماً بجميع المكملات التي تتناولها.
            

        

        

        
        
        

            

  
Related Ingredients





            

                
                
                    Hawthorn
                    
                
                
                
                    Curcumin
                    
                
                
                
                    Berberine
                    
                
                
                
                    Red Yeast Rice
                    
                
                
            

        

        
    


    
    












    

        إخلاء مسؤولية FDA:
        لم تُقيَّم هذه البيانات من قبل إدارة الغذاء والدواء (FDA). لا تهدف المنتجات والمعلومات الواردة في هذا الموقع إلى تشخيص أو علاج أو شفاء أو الوقاية من أي مرض. تستند تقييمات الأدلة المعروضة إلى تحليلنا للأبحاث المحكّمة المنشورة ولا تُشكّل نصيحة طبية. استشر مقدم الرعاية الصحية دائماً قبل البدء بأي نظام مكملات.