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HeartCited

Vitamin K2 用于 Arterial Stiffness

B

Rotterdam Heart Study: 57% lower CV mortality with highest K2 intake. KNAPEN RCT: MK-7 (180 mcg/day, 3 years) significantly improved arterial stiffness in postmenopausal women.

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            B

        

        

            
结论

            
            
Rotterdam Heart Study: 57% lower CV mortality with highest K2 intake. KNAPEN RCT: MK-7 (180 mcg/day, 3 years) significantly improved arterial stiffness in postmenopausal women.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
5

        
研究数量

    

    

        
1200

        
受试者

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
等级

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
常用剂量

                

                    
                    

                        
general:

                        
90-120 mcg/day (MK-7 preferred)

                    

                    
                    

                        
cardiovascularsupport:

                        
180-360 mcg/day MK-7

                    

                    
                

                
                

                    上限： Not established (no known toxicity for K2 at supplemental doses)
                

                
            

            

            

            
            

                最佳服用时间： With meals containing fat; can combine with vitamin D supplement
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
已报告的副作用

                    
    
                        
                        
  • 
                            ⚠
                            Generally very well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Does not affect blood clotting (INR) at supplemental doses, unlike K1
                        
    • 
                        
                    

                

                

                
                

                    
已知相互作用

                    
    
                        
                        
  • 
                            ●
                            Warfarin (patients on warfarin should consult physician before K2 supplementation)
                        
    • 
                        
                        
  • 
                            ●
                            Vitamin D (synergistic — D increases MGP production, K2 activates it)
                        
    • 
                        
                    

                

                

                
                

                    

                        可耐受最高摄入量： Not established (no known toxicity for K2 at supplemental doses)
                    

                

                
            

            

                在开始服用任何补充剂之前，请务必咨询您的医疗保健提供者。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Vitamin K2 help with Arterial Stiffness?
            
        
        

            Based on 5 studies with 1,200 participants, there is moderate evidence from clinical studies that Vitamin K2 may support Arterial Stiffness management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Vitamin K2 should I take for Arterial Stiffness?
            
        
        

            Studies have used various dosages. A commonly studied range is 90-120 mcg/day (MK-7 preferred). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Vitamin K2?
            
        
        

            Reported side effects may include Generally very well-tolerated, Does not affect blood clotting (INR) at supplemental doses, unlike K1. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Vitamin K2 and Arterial Stiffness?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
其他成分用于 Arterial Stiffness

                    

                        
                        
                            NMN (Nicotinamide Mononucleotide)
                            C

                        
                        
                    

                

                

                
            

        

        

    


    
    












    

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