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PQQ (Pyrroloquinoline Quinone) for Oxidative Stress (Cardiovascular)

C Some Evidence Limited evidence from small studies, but some positive signals exist.

Small RCT showed LDL and CRP reduction. Exceptional antioxidant potency. Cardiovascular-specific human data is very limited despite strong preclinical evidence.

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            C

        

        

            
The Bottom Line

            
            
Small RCT showed LDL and CRP reduction. Exceptional antioxidant potency. Cardiovascular-specific human data is very limited despite strong preclinical evidence.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Review
                
                
                
                
            

            
                Nutraceutical activation of Sirt1: a review.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Sirt1 activation and healthspan
                
                
                Effect: None
                
                
                None
                
            

            
            
Population: General/aging population

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
2

        
Studies

    

    

        
100

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        C

        
Grade

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Nutraceutical activation of Sirt1: a review.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Open heart
                        2022
                        
                        52 citations
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
10-20 mg/day

                    

                    
                    

                        
cardiovascularsupport:

                        
20 mg/day

                    

                    
                

                
                

                    Upper limit: Not formally established; up to 60 mg/day used in short-term studies
                

                
            

            

            
            

                
Dosages Studied in Research

                

                    

                        
                            

                                Dosage
                                Duration
                                Effect
                                N
                            

                        
                        
                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Best taken: With or without food
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
  • 
                            ⚠
                            Generally well-tolerated
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild headache (rare)
                        
    • 
                        
                        
  • 
                            ⚠
                            Mild gastrointestinal discomfort (rare)
                        
    • 
                        
                    

                

                

                
                

                    
Known Interactions

                    
    
                        
                        
  • 
                            ●
                            May enhance effects of CoQ10 (synergistic mitochondrial support)
                        
    • 
                        
                        
  • 
                            ●
                            Theoretical interaction with anticoagulants
                        
    • 
                        
                    

                

                

                
                

                    

                        Tolerable upper intake: Not formally established; up to 60 mg/day used in short-term studies
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does PQQ (Pyrroloquinoline Quinone) help with Oxidative Stress (Cardiovascular)?
            
        
        

            Based on 2 studies with 100 participants, there is limited but promising evidence that PQQ (Pyrroloquinoline Quinone) may support Oxidative Stress (Cardiovascular) management. Our evidence grade is C (Some Evidence).
        

    

    
    

        
            How much PQQ (Pyrroloquinoline Quinone) should I take for Oxidative Stress (Cardiovascular)?
            
        
        

            Studies have used various dosages. A commonly studied range is 10-20 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of PQQ (Pyrroloquinoline Quinone)?
            
        
        

            Reported side effects may include Generally well-tolerated, Mild headache (rare), Mild gastrointestinal discomfort (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for PQQ (Pyrroloquinoline Quinone) and Oxidative Stress (Cardiovascular)?
            
        
        

            We rate the evidence as Grade C (Some Evidence). This rating is based on 2 peer-reviewed studies with 100 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
Other ingredients for Oxidative Stress (Cardiovascular)

                    

                        
                        
                            Selenium
                            B

                        
                        
                    

                

                

                
                

                    
PQQ (Pyrroloquinoline Quinone) for other conditions

                    

                        
                        
                            Heart Failure
                            D

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      James J DiNicolantonio et al..
      Open Heart.
      2022.
      Nutraceutical activation of Sirt1: a review.
      doi:10.1136/openhrt-2022-002171
      PubMed
    
    2. 
    
  















    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.