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PQQ (Pyrroloquinoline Quinone) for Heart Failure

D

Animal studies show PQQ may help reduce infarct size in ischemia-reperfusion models. No human heart failure trials. Mitochondrial biogenesis mechanism may be relevant.

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The Bottom Line

            
            
Animal studies show PQQ may help reduce infarct size in ischemia-reperfusion models. No human heart failure trials. Mitochondrial biogenesis mechanism may be relevant.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
0

        
Studies

    

    

        
--

        
Participants

    

    

        
            
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Positive

    

    

        D

        
Grade

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
10-20 mg/day

                    

                    
                    

                        
cardiovascularsupport:

                        
20 mg/day

                    

                    
                

                
                

                    Upper limit: Not formally established; up to 60 mg/day used in short-term studies
                

                
            

            

            

            
            

                Best taken: With or without food
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
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                            ⚠
                            Generally well-tolerated
                        
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                            ⚠
                            Mild headache (rare)
                        
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                            Mild gastrointestinal discomfort (rare)
                        
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Known Interactions

                    
    
                        
                        
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                            ●
                            May enhance effects of CoQ10 (synergistic mitochondrial support)
                        
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                            ●
                            Theoretical interaction with anticoagulants
                        
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                        Tolerable upper intake: Not formally established; up to 60 mg/day used in short-term studies
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does PQQ (Pyrroloquinoline Quinone) help with Heart Failure?
            
        
        

            Based on 0 studies with 0 participants, there is preliminary evidence that needs more research that PQQ (Pyrroloquinoline Quinone) may support Heart Failure management. Our evidence grade is D (Very Early Research).
        

    

    
    

        
            How much PQQ (Pyrroloquinoline Quinone) should I take for Heart Failure?
            
        
        

            Studies have used various dosages. A commonly studied range is 10-20 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of PQQ (Pyrroloquinoline Quinone)?
            
        
        

            Reported side effects may include Generally well-tolerated, Mild headache (rare), Mild gastrointestinal discomfort (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for PQQ (Pyrroloquinoline Quinone) and Heart Failure?
            
        
        

            We rate the evidence as Grade D (Very Early Research). This rating is based on 0 peer-reviewed studies with 0 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                
                

                
                

                    
PQQ (Pyrroloquinoline Quinone) for other conditions

                    

                        
                        
                            Oxidative Stress (Cardiovascular)
                            C

                        
                        
                    

                

                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.