What is the recommended dosage for Omega-3 Fatty Acids (EPA/DHA)?

General: 1,000 mg combined EPA/DHA per day; Triglyceride Reduction: 2,000-4,000 mg/day (prescription-grade)

What are the side effects of Omega-3 Fatty Acids (EPA/DHA)?

Potential side effects include: Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May increase atrial fibrillation risk at doses >2g/day.

What are omega-3 EPA and DHA and how may they support heart health?

EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are long-chain omega-3 fatty acids found in fatty fish. Large clinical trials including REDUCE-IT have shown that high-dose EPA (4g/day icosapent ethyl) significantly reduces cardiovascular events. EPA and DHA may lower triglycerides, reduce inflammation, and support healthy heart rhythm.

What dosage of omega-3 EPA/DHA has been studied for cardiovascular health?

For triglyceride reduction, clinical trials have used 2–4 grams of combined EPA+DHA daily. The REDUCE-IT trial used 4g/day of pure EPA (icosapent ethyl). The American Heart Association recommends 1g/day EPA+DHA for patients with coronary heart disease. General cardiovascular support studies use 1–2g daily.

What are the potential side effects of omega-3 EPA/DHA supplements?

Common side effects include fishy aftertaste, burping, and gastrointestinal discomfort. High doses (above 3g/day) may increase bleeding time and should be used cautiously with anticoagulants. The REDUCE-IT trial noted a small increase in atrial fibrillation with high-dose EPA. Enteric-coated capsules may reduce GI side effects.

Omega-3 Fatty Acids (EPA/DHA)
Omega-3 Fatty Acids (EPA/DHA)

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Также известен как: Fish Oil, Marine Omega-3, Eicosapentaenoic Acid, Docosahexaenoic Acid, EPA, DHA

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About

Omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are long-chain polyunsaturated fats from marine sources that support cardiovascular health through multiple mechanisms. EPA/DHA incorporate into cell membranes, modulate inflammatory signaling, lower plasma triglycerides, and improve endothelial function. The REDUCE-IT trial demonstrated that high-dose EPA (4g/day) reduced major adverse cardiovascular events by 25%.

How It Works

Long-chain polyunsaturated fatty acids that incorporate into cell membranes modulating inflammatory signaling via reduced arachidonic acid conversion to pro-inflammatory eicosanoids; lower plasma triglycerides by reducing hepatic VLDL production and increasing lipoprotein lipase activity; improve endothelial function by enhancing nitric oxide bioavailability; stabilize cardiac myocyte membranes reducing arrhythmia susceptibility through ion channel modulation.

Evidence For Conditions

Состояние	Оценка	Исследования	Участники
High Triglycerides (Hypertriglyceridemia)	A	50	20000	Подробнее →
Coronary Artery Disease (CAD)	B	20	50000	Подробнее →
Cardiac Arrhythmia	B	15	10000	Подробнее →

Side Effects

Fishy aftertaste or burping
Mild gastrointestinal discomfort
Potential increased bleeding time at very high doses
May increase atrial fibrillation risk at doses >2g/day

Drug & Supplement Interactions

Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
Blood pressure medications (additive hypotensive effect)
Orlistat (may reduce omega-3 absorption)

Всегда сообщайте лечащему врачу обо всех принимаемых добавках.

Related Ingredients

Krill Oil Omega-7 (Palmitoleic Acid) Flaxseed Oil

Основные факты

Дозировка: General: 1,000 mg combined EPA/DHA per day; Triglyceride_Reduction: 2,000-4,000 mg/day (prescription-grade)
Формы выпуска: softgel liquid capsule enteric-coated
Природные источники: Fatty fish (salmon, mackerel, sardines, anchovies), Algae, Krill, Fish roe, Grass-fed beef
Верхний предел: 5,000 mg/day combined EPA/DHA (FDA GRAS up to 3,000 mg/day from supplements)
Лучшее время приёма: With meals containing fat for optimal absorption; divide doses >2,000 mg

Обзор доказательной базы

High Triglycerides (Hypertriglyceridemia) A

Coronary Artery Disease (CAD) B

Cardiac Arrhythmia B

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.

Omega-3 Fatty Acids (EPA/DHA)Omega-3 Fatty Acids (EPA/DHA)