What is the recommended dosage for Curcumin?

Standard Curcumin: 500-2,000 mg/day; Enhanced Bioavailability: 80-500 mg/day (Theracurmin, Longvida, Meriva)

What are the side effects of Curcumin?

Potential side effects include: Gastrointestinal discomfort (nausea, diarrhea), Yellow staining of skin/teeth at high doses, May increase gallbladder contractions, Headache (rare).

What is curcumin and how may it support cardiovascular health?

Curcumin is the primary bioactive compound in turmeric with anti-inflammatory and antioxidant properties. Clinical studies suggest it may improve endothelial function, reduce arterial stiffness, and lower inflammatory markers such as CRP and IL-6. However, its extremely low bioavailability limits therapeutic potential without enhanced formulations.

What dosage of curcumin has been studied for cardiovascular health?

Clinical trials have used 500–2,000 mg of curcumin per day, typically in bioavailability-enhanced forms (piperine-enhanced, liposomal, or nano-formulations). Standard curcumin has only 1–2% bioavailability. Enhanced formulations may increase absorption 20–185 fold. Study durations ranged from 4 to 24 weeks.

What are the potential side effects of curcumin supplements?

Common side effects include digestive discomfort, nausea, and diarrhea. Curcumin may have antiplatelet effects and should be used cautiously with anticoagulants. It may interact with drugs metabolized by CYP enzymes. Piperine-enhanced formulations may affect the metabolism of many medications. Individuals with gallbladder disease should exercise caution.

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Curcumin

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Также известен как: Turmeric Extract, Curcuma longa, Diferuloylmethane, Theracurmin, Longvida, Meriva

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About

Curcumin, the active compound in turmeric, is a potent modulator of vascular inflammation through NF-kB, JAK/STAT, and MAPK pathway inhibition. A 2017 meta-analysis found curcumin significantly reduced total cholesterol, LDL, and triglycerides in metabolic syndrome patients. Enhanced bioavailability formulations (Theracurmin, Longvida, Meriva) provide 25-185x improvements over standard curcumin.

How It Works

Potent modulator of vascular inflammation through NF-kB, JAK/STAT, and MAPK pathway inhibition; reduces endothelial expression of adhesion molecules decreasing monocyte recruitment; improves endothelial function by enhancing eNOS expression and nitric oxide bioavailability; reduces ox-LDL uptake by macrophages inhibiting foam cell formation; anti-thrombotic activity via COX-2 inhibition.

Evidence For Conditions

Состояние	Оценка	Исследования	Участники
Cardiovascular Inflammation	B	12	1000	Подробнее →
High Cholesterol (Hyperlipidemia)	C	7	500	Подробнее →

Side Effects

Gastrointestinal discomfort (nausea, diarrhea)
Yellow staining of skin/teeth at high doses
May increase gallbladder contractions
Headache (rare)

Drug & Supplement Interactions

Anticoagulants (may increase bleeding risk)
Antiplatelet drugs (additive antiplatelet effect)
Diabetes medications (may lower blood sugar)
CYP3A4 substrates (may alter metabolism)
Iron supplements (curcumin may chelate iron)

Всегда сообщайте лечащему врачу обо всех принимаемых добавках.

Related Ingredients

Hawthorn Garlic Berberine Red Yeast Rice

Основные факты

Дозировка: Standard_Curcumin: 500-2,000 mg/day; Enhanced_Bioavailability: 80-500 mg/day (Theracurmin, Longvida, Meriva)
Формы выпуска: capsule tablet powder liquid
Природные источники: Turmeric root (Curcuma longa), Curry powder
Верхний предел: Not formally established; up to 8,000 mg/day standard curcumin used in trials
Лучшее время приёма: With meals containing fat and black pepper; divide doses for standard curcumin

Обзор доказательной базы

Cardiovascular Inflammation B

High Cholesterol (Hyperlipidemia) C

Отказ от ответственности FDA: Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.