What is the recommended dosage for Omega-3 Fatty Acids (EPA/DHA)?

General: 1,000 mg combined EPA/DHA per day; Triglyceride Reduction: 2,000-4,000 mg/day (prescription-grade)

What are the side effects of Omega-3 Fatty Acids (EPA/DHA)?

Potential side effects include: Fishy aftertaste or burping, Mild gastrointestinal discomfort, Potential increased bleeding time at very high doses, May increase atrial fibrillation risk at doses >2g/day.

What are omega-3 EPA and DHA and how may they support heart health?

EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are long-chain omega-3 fatty acids found in fatty fish. Large clinical trials including REDUCE-IT have shown that high-dose EPA (4g/day icosapent ethyl) significantly reduces cardiovascular events. EPA and DHA may lower triglycerides, reduce inflammation, and support healthy heart rhythm.

What dosage of omega-3 EPA/DHA has been studied for cardiovascular health?

For triglyceride reduction, clinical trials have used 2–4 grams of combined EPA+DHA daily. The REDUCE-IT trial used 4g/day of pure EPA (icosapent ethyl). The American Heart Association recommends 1g/day EPA+DHA for patients with coronary heart disease. General cardiovascular support studies use 1–2g daily.

What are the potential side effects of omega-3 EPA/DHA supplements?

Common side effects include fishy aftertaste, burping, and gastrointestinal discomfort. High doses (above 3g/day) may increase bleeding time and should be used cautiously with anticoagulants. The REDUCE-IT trial noted a small increase in atrial fibrillation with high-dose EPA. Enteric-coated capsules may reduce GI side effects.

Omega-3 Fatty Acids (EPA/DHA)
Omega-3 Fatty Acids (EPA/DHA)

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다른 이름: Fish Oil, Marine Omega-3, Eicosapentaenoic Acid, Docosahexaenoic Acid, EPA, DHA

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About

Omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are long-chain polyunsaturated fats from marine sources that support cardiovascular health through multiple mechanisms. EPA/DHA incorporate into cell membranes, modulate inflammatory signaling, lower plasma triglycerides, and improve endothelial function. The REDUCE-IT trial demonstrated that high-dose EPA (4g/day) reduced major adverse cardiovascular events by 25%.

How It Works

Long-chain polyunsaturated fatty acids that incorporate into cell membranes modulating inflammatory signaling via reduced arachidonic acid conversion to pro-inflammatory eicosanoids; lower plasma triglycerides by reducing hepatic VLDL production and increasing lipoprotein lipase activity; improve endothelial function by enhancing nitric oxide bioavailability; stabilize cardiac myocyte membranes reducing arrhythmia susceptibility through ion channel modulation.

Evidence For Conditions

건강 상태	등급	연구	참여자
High Triglycerides (Hypertriglyceridemia)	A	50	20000	보기 →
Coronary Artery Disease (CAD)	B	20	50000	보기 →
Cardiac Arrhythmia	B	15	10000	보기 →

Side Effects

Fishy aftertaste or burping
Mild gastrointestinal discomfort
Potential increased bleeding time at very high doses
May increase atrial fibrillation risk at doses >2g/day

Drug & Supplement Interactions

Anticoagulants and antiplatelet drugs (may increase bleeding risk at high doses)
Blood pressure medications (additive hypotensive effect)
Orlistat (may reduce omega-3 absorption)

복용 중인 모든 건강기능식품에 대해 반드시 의료 전문가에게 알리십시오.

Related Ingredients

Krill Oil Omega-7 (Palmitoleic Acid) Flaxseed Oil

핵심 정보

용량: General: 1,000 mg combined EPA/DHA per day; Triglyceride_Reduction: 2,000-4,000 mg/day (prescription-grade)
제형: softgel liquid capsule enteric-coated
천연 원료: Fatty fish (salmon, mackerel, sardines, anchovies), Algae, Krill, Fish roe, Grass-fed beef
상한 섭취량: 5,000 mg/day combined EPA/DHA (FDA GRAS up to 3,000 mg/day from supplements)
권장 복용 시간: With meals containing fat for optimal absorption; divide doses >2,000 mg

근거 요약

High Triglycerides (Hypertriglyceridemia) A

Coronary Artery Disease (CAD) B

Cardiac Arrhythmia B

FDA 면책 조항: 이 내용은 미국 식품의약국(FDA)의 평가를 받지 않았습니다. 이 웹사이트의 제품 및 정보는 질병의 진단, 치료, 완치 또는 예방을 목적으로 하지 않습니다. 제시된 근거 등급은 발표된 동료 심사 연구에 대한 우리의 분석에 기반하며, 의학적 조언을 구성하지 않습니다. 건강기능식품 복용을 시작하기 전에 반드시 의료 전문가와 상담하십시오.

Omega-3 Fatty Acids (EPA/DHA)Omega-3 Fatty Acids (EPA/DHA)