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Serum sodium and potassium levels measured during chronic metabolic acidosis. Electrolyte imbalances, particularly in potassium homeostasis, are closely linked to both acid-base disturbances and blood pressure regulation through renal and vascular mechanisms.
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Figure 6
Blood pressure measurements by tail-cuff method showing significant changes in mean arterial pressure across treatment groups. Chronic metabolic acidosis elicited a hypertensive response, supporting the hypothesis that sustained acid-base imbalance directly contributes to elevated blood pressure.
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Figure 7
Renal tissue analysis or additional hemodynamic data from the chronic metabolic acidosis hypertension study. The intrarenal measurements help delineate the local versus systemic mechanisms driving the blood pressure response.
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Figure 8
Molecular or biochemical analysis of kidney tissue from animals with chronic metabolic acidosis. The data examine expression of inducible nitric oxide synthase and angiotensin pathway components in the renal cortex.
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Figure 9
Urinary sodium excretion analysis across experimental groups reveals altered renal sodium handling during chronic metabolic acidosis. Changes in sodium reabsorption may contribute to the volume-dependent component of acidosis-induced hypertension.
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Figure 11
Plasma aldosterone and plasma renin measurements indicate activation of the systemic renin-angiotensin-aldosterone system during chronic metabolic acidosis. Elevated aldosterone levels suggest enhanced sodium retention and potassium excretion as contributors to the hypertensive phenotype.
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Figure 12
Figure 10
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Chronic Metabolic Acidosis Elicits Hypertension via Upregulation of Intrarenal Angiotensin II and Induction of Oxidative Stress.Cite This Figure
 > Source: Dinesh Aryal et al. "Chronic Metabolic Acidosis Elicits Hypertension via Upregulation of Intrarenal A." *Antioxidants (Basel, Switzerland)*, 2020. PMID: [33374943](https://pubmed.ncbi.nlm.nih.gov/33374943/)
<figure> <img src="https://pdfs.citedhealth.com/figures/33374943/132.png" alt="Serum sodium and potassium levels measured during chronic metabolic acidosis. Electrolyte imbalances, particularly in potassium homeostasis, are closely linked to both acid-base disturbances and blood pressure regulation through renal and vascular mechanisms." /> <figcaption>Figure 10. Serum sodium and potassium levels measured during chronic metabolic acidosis. Electrolyte imbalances, particularly in potassium homeostasis, are closely linked to both acid-base disturbances and blood pressure regulation through renal and vascular mechanisms.<br> Source: Dinesh Aryal et al. "Chronic Metabolic Acidosis Elicits Hypertension via Upregulation of Intrarenal A." <em>Antioxidants (Basel, Switzerland)</em>, 2020. PMID: <a href="https://pubmed.ncbi.nlm.nih.gov/33374943/">33374943</a></figcaption> </figure>