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Curcumin ： Cardiovascular Inflammation

B エビデンス 少なくとも1件のランダム化試験がこれを支持しており、おおむね一貫した結果が得られています。

Meta-analyses confirm reduction in CRP, IL-6, and TNF-alpha. Improved endothelial function (FMD) in multiple RCTs. Enhanced bioavailability formulations necessary for clinical effect.

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            B

        

        

            
結論

            
            
Meta-analyses confirm reduction in CRP, IL-6, and TNF-alpha. Improved endothelial function (FMD) in multiple RCTs. Enhanced bioavailability formulations necessary for clinical effect.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                
                Double-blind
                
            

            
                Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with …
            
            

                
                Dose: 2000 mg/d
                
                
                vs: Placebo
                
                
                Outcome: independent effects of fish oil and curcumin and …
                
                
                効果: None
                
                
                P = 0.023
                
            

            
            
対象集団: Older adults at risk of cognitive decline

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: None
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: None

            
        

        
        

            

                
                    Review
                
                
                
                
            

            
                Therapeutic roles of curcumin: lessons learned from clinical trials.
            
            

                
                Dose: None
                
                
                vs: None
                
                
                Outcome: Efficacy in cancer, CVD, arthritis, IBD and other …
                
                
                効果: None
                
                
                None
                
            

            
            
対象集団: Patients with various pro-inflammatory diseases

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
12

        
研究数

    

    

        
1000

        
参加者数

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
グレード

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        The Journal of …
                        2020
                        
                        33 件の引用
                        
                    

                

                
                

                    

                        
                            Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        Frontiers in immunology
                        2018
                        
                        200 件の引用
                        
                    

                

                
                

                    

                        
                            Therapeutic roles of curcumin: lessons learned from clinical trials.
                        
                        
                            
                                Review
                            
                            
                            
                        
                    

                    

                        The AAPS journal
                        2013
                        
                        1866 件の引用
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
一般的な使用量

                

                    
                    

                        
standardcurcumin:

                        
500-2,000 mg/day

                    

                    
                    

                        
enhancedbioavailability:

                        
80-500 mg/day (Theracurmin, Longvida, Meriva)

                    

                    
                

                
                

                    上限量： Not formally established; up to 8,000 mg/day standard curcumin used in trials
                

                
            

            

            
            

                
研究で検討された用量

                

                    

                        
                            

                                用量
                                期間
                                効果
                                N
                            

                        
                        
                            
                            

                                2000 mg/d
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                            

                                None
                                --
                                
                                    
                                    Positive
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                推奨摂取タイミング： With meals containing fat and black pepper; divide doses for standard curcumin
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
報告されている副作用

                    
    
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort (nausea, diarrhea)
                        
    • 
                        
                        
  • 
                            ⚠
                            Yellow staining of skin/teeth at high doses
                        
    • 
                        
                        
  • 
                            ⚠
                            May increase gallbladder contractions
                        
    • 
                        
                        
  • 
                            ⚠
                            Headache (rare)
                        
    • 
                        
                    

                

                

                
                

                    
既知の相互作用

                    
    
                        
                        
  • 
                            ●
                            Anticoagulants (may increase bleeding risk)
                        
    • 
                        
                        
  • 
                            ●
                            Antiplatelet drugs (additive antiplatelet effect)
                        
    • 
                        
                        
  • 
                            ●
                            Diabetes medications (may lower blood sugar)
                        
    • 
                        
                        
  • 
                            ●
                            CYP3A4 substrates (may alter metabolism)
                        
    • 
                        
                        
  • 
                            ●
                            Iron supplements (curcumin may chelate iron)
                        
    • 
                        
                    

                

                

                
                

                    

                        耐容上限摂取量： Not formally established; up to 8,000 mg/day standard curcumin used in trials
                    

                

                
            

            

                サプリメントの摂取を開始する前に、必ず医療専門家にご相談ください。
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Curcumin help with Cardiovascular Inflammation?
            
        
        

            Based on 12 studies with 1,000 participants, there is moderate evidence from clinical studies that Curcumin may support Cardiovascular Inflammation management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Curcumin should I take for Cardiovascular Inflammation?
            
        
        

            Studies have used various dosages. A commonly studied range is 500-2,000 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Curcumin?
            
        
        

            Reported side effects may include Gastrointestinal discomfort (nausea, diarrhea), Yellow staining of skin/teeth at high doses, May increase gallbladder contractions, Headache (rare). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Curcumin and Cardiovascular Inflammation?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 12 peer-reviewed studies with 1,000 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
に関する他の成分： Cardiovascular Inflammation

                    

                        
                        
                            Krill Oil
                            D

                        
                        
                    

                

                

                
                

                    
Curcumin 他の症状・状態について

                    

                        
                        
                            High Cholesterol (Hyperlipidemia)
                            C

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Julia C Kuszewski et al..
      J Nutr.
      2020.
      Evaluation of Cognitive Performance following Fish-Oil and Curcumin Supplementation in Middle-Aged and Older Adults with Overweight or Obesity.
      doi:10.1093/jn/nxaa299
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Subash Chandra Gupta et al..
      Front Immunol.
      2018.
      Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.
      doi:10.3389/fimmu.2018.02160
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Subash C Gupta et al..
      AAPS J.
      2013.
      Therapeutic roles of curcumin: lessons learned from clinical trials.
      doi:10.1208/s12248-012-9432-8
      PubMed
    
    4. 
    
  















    

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