What is the recommended dosage for Olive Leaf Extract?

General: 500 mg BID; Oleuropein Content: 15-20% standardization; Standardized Extract: 500-1,000 mg/day (EFLA 943)

What are the side effects of Olive Leaf Extract?

Potential side effects include: Generally well-tolerated, Mild gastrointestinal discomfort, Dizziness (if blood pressure drops significantly), Headache (rare).

What is olive leaf extract and how may it support cardiovascular health?

Olive leaf extract contains oleuropein and hydroxytyrosol, polyphenols with antioxidant, anti-inflammatory, and vasodilatory properties. A clinical trial found olive leaf extract (500 mg twice daily) reduced blood pressure comparably to captopril in stage 1 hypertension. It may also improve lipid profiles.

What dosage of olive leaf extract has been studied for cardiovascular benefits?

Clinical studies have used 500–1,000 mg of olive leaf extract per day, standardized to 15–20% oleuropein. The blood pressure study used 500 mg twice daily for 8 weeks. Most formulations are standardized to oleuropein content. Study durations ranged from 4 to 12 weeks.

What are the potential side effects of olive leaf extract?

Olive leaf extract is generally well tolerated. Some individuals experience digestive discomfort, dizziness, or headache. It may lower blood pressure and blood sugar, so caution is needed when combined with antihypertensives or diabetes medications. A temporary increase in symptoms (Herxheimer-like reaction) has been reported anecdotally.

Olive Leaf Extract
Olive Leaf Extract

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Noto anche come: Olea europaea Extract, Oleuropein, Hydroxytyrosol, EFLA 943, Benolea

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About

Olive leaf extract contains oleuropein and hydroxytyrosol — the most potent natural antioxidant measured by ORAC — with ACE-inhibitory activity. A landmark 2011 RCT (148 hypertensive patients) found olive leaf extract at 500 mg BID reduced systolic blood pressure by 11.5 mmHg — comparable to captopril. EFSA has approved a health claim for olive oil polyphenols protecting LDL from oxidation.

How It Works

Oleuropein inhibits ACE activity reducing angiotensin II-mediated vasoconstriction; enhances endothelial nitric oxide production; potent antioxidant activity protects LDL from oxidation (hydroxytyrosol is the most potent natural antioxidant by ORAC); anti-inflammatory via NF-kB and COX-2 inhibition; improves arterial elasticity.

Evidence For Conditions

Condizione	Grado	Studi	Partecipanti
High Blood Pressure (Hypertension)	B	5	500	Visualizza →
Atherosclerosis	D	2	100	Visualizza →

Side Effects

Generally well-tolerated
Mild gastrointestinal discomfort
Dizziness (if blood pressure drops significantly)
Headache (rare)

Drug & Supplement Interactions

Antihypertensives (additive blood pressure lowering — monitor BP)
Diabetes medications (may lower blood sugar)
Anticoagulants (mild theoretical interaction)

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Informazioni rapide

Dosaggio: General: 500 mg BID; Oleuropein_Content: 15-20% standardization; Standardized_Extract: 500-1,000 mg/day (EFLA 943)
Forme: capsule tablet liquid extract tea
Fonti naturali: Olive leaves, Extra virgin olive oil, Olives
Limite massimo: Not formally established; well-tolerated up to 1,000 mg/day in clinical trials
Momento migliore: With meals

Riepilogo delle evidenze

High Blood Pressure (Hypertension) B

Atherosclerosis D

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Avvertenza FDA: Queste affermazioni non sono state valutate dalla Food and Drug Administration. I prodotti e le informazioni presenti su questo sito web non sono destinati a diagnosticare, trattare, curare o prevenire alcuna malattia. I gradi di evidenza presentati si basano sulla nostra analisi della ricerca pubblicata e sottoposta a revisione paritaria e non costituiscono consulenza medica. Consultate sempre il vostro medico prima di iniziare qualsiasi regime di integrazione.