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HeartCited

Psyllium

fiber

Also known as: Psyllium Husk, Ispaghula, Metamucil, Plantago ovata

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About

Psyllium is a soluble gel-forming fiber with an FDA-approved health claim for cholesterol reduction. A 2018 meta-analysis of 28 RCTs found psyllium at 10g/day reduced LDL cholesterol by 12.5 mg/dL. The AHA/ACC endorse psyllium as part of therapeutic lifestyle changes for hypercholesterolemia.

How It Works

Soluble gel-forming fiber that binds bile acids in the intestinal lumen, forcing the liver to use circulating cholesterol to synthesize new bile acids, thereby reducing LDL cholesterol; forms a viscous gel slowing glucose absorption and reducing postprandial insulin spikes; promotes beneficial gut bacteria fermentation producing short-chain fatty acids.

Evidence For Conditions

Condition Grade Studies Participants
High Cholesterol (Hyperlipidemia) A 28 2000 View →

Side Effects

  • Bloating and gas (especially when starting — resolves with gradual titration)
  • Abdominal cramping
  • Choking hazard if taken without adequate water
  • Allergic reactions (rare, in healthcare workers with occupational exposure)

Drug & Supplement Interactions

  • All oral medications (may reduce absorption — take medications 1-2 hours before psyllium)
  • Diabetes medications (additive blood sugar lowering effect)
  • Lithium (may reduce absorption)
  • Carbamazepine (may reduce absorption)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.