What is the recommended dosage for Omega-7 (Palmitoleic Acid)?

General: 210-420 mg/day purified palmitoleic acid

What are the side effects of Omega-7 (Palmitoleic Acid)?

Potential side effects include: Mild gastrointestinal discomfort, May interact with blood-thinning medications at high doses.

What is omega-7 and how may it relate to cardiovascular health?

Omega-7 (palmitoleic acid) is a monounsaturated fatty acid found in sea buckthorn oil and macadamia nuts. Preliminary research suggests it may improve lipid profiles by reducing triglycerides and LDL cholesterol while raising HDL. The evidence base is early-stage compared to omega-3 fatty acids.

What dosage of omega-7 has been studied in clinical trials?

Limited clinical studies have used 210–420 mg of purified palmitoleic acid per day. The most cited trial used a purified omega-7 supplement at 220 mg daily for 30 days. More research is needed to establish optimal dosing for cardiovascular outcomes.

What are the potential side effects of omega-7 supplements?

Omega-7 supplements are generally well tolerated. Mild digestive discomfort has been reported. Some sea buckthorn-derived products may contain palmitic acid, a saturated fat that could negatively affect lipid profiles. Choose purified omega-7 products with minimal palmitic acid content.

Omega-7 (Palmitoleic Acid)

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Also known as: Palmitoleic Acid, Sea Buckthorn Oil, Provinal, cis-Palmitoleic Acid

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About

Omega-7, or palmitoleic acid, is a monounsaturated fatty acid that acts as a lipokine — a lipid hormone signaling between adipose tissue and other organs. A 2014 Cleveland Clinic RCT found purified palmitoleic acid reduced CRP by 44% and triglycerides by 15%, though the evidence base remains small.

How It Works

A monounsaturated fatty acid that acts as a lipokine signaling between adipose tissue and other organs; supports healthy lipid metabolism by suppressing hepatic de novo lipogenesis via SREBP-1c downregulation; may support endothelial function and reduce inflammatory markers (CRP, IL-6) through NF-kB pathway modulation.

Evidence For Conditions

Condition	Grade	Studies	Participants
High Triglycerides (Hypertriglyceridemia)	C	2	100	View →
Atherosclerosis	D	1	60	View →

Side Effects

Mild gastrointestinal discomfort
May interact with blood-thinning medications at high doses

Drug & Supplement Interactions

Anticoagulants (theoretical additive effect)
Lipid-lowering medications (may have additive effects)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Flaxseed Oil Krill Oil Omega-3 Fatty Acids (EPA/DHA)

Quick Facts

Dosage: General: 210-420 mg/day purified palmitoleic acid
Forms: softgel capsule
Natural Sources: Sea buckthorn berries, Macadamia nuts, Anchovy/sardine-derived (purified)
Upper Limit: Not formally established
Best Time: With meals

Evidence Summary

High Triglycerides (Hypertriglyceridemia) C

Atherosclerosis D

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.