What is the recommended dosage for NMN (Nicotinamide Mononucleotide)?

General: 250-500 mg/day; Anti Aging Protocols: 500-1,000 mg/day

What are the side effects of NMN (Nicotinamide Mononucleotide)?

Potential side effects include: Generally well-tolerated, Mild gastrointestinal discomfort, Flushing (rare), Headache (rare).

What is NMN and how may it relate to cardiovascular health?

Nicotinamide mononucleotide (NMN) is a precursor to NAD+, a coenzyme involved in cellular energy production and DNA repair. Animal studies suggest NMN may improve vascular function and protect against age-related cardiovascular decline. Human clinical trials are ongoing, and cardiovascular-specific evidence is preliminary.

What dosage of NMN has been studied in clinical trials?

Early human studies have used 250–1,250 mg of NMN per day. The optimal dosage for cardiovascular outcomes has not been established. Most human studies have focused on safety, NAD+ levels, and metabolic parameters rather than cardiovascular endpoints. Larger, longer-term trials are needed.

What are the potential side effects of NMN supplements?

In short-term studies, NMN appears well tolerated. Mild side effects include nausea and headache. The long-term safety profile has not been established. NMN's regulatory status varies by country; the FDA issued a letter questioning its classification as a dietary supplement. Quality and purity may vary between products.

NMN (Nicotinamide Mononucleotide)

coenzyme

Also known as: Nicotinamide Mononucleotide, beta-NMN, NAD+ Precursor

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About

NMN is a direct precursor to NAD+, a critical coenzyme for mitochondrial energy metabolism and sirtuin-mediated cellular repair. NAD+ levels decline approximately 50% between ages 40-60, correlating with cardiovascular aging. A 2024 RCT showed NMN at 250 mg/day improved arterial stiffness and reduced aortic pulse wave velocity in middle-aged adults.

How It Works

Direct precursor to NAD+ (nicotinamide adenine dinucleotide), a critical coenzyme for mitochondrial energy metabolism, sirtuin-mediated DNA repair, and PARP-mediated stress response; supports endothelial function by restoring SIRT1 activity in vascular smooth muscle; activates AMPK improving metabolic health markers associated with cardiovascular risk.

Evidence For Conditions

Condition	Grade	Studies	Participants
Arterial Stiffness	C	2	100	View →
Heart Failure	D	0	--	View →

Side Effects

Generally well-tolerated
Mild gastrointestinal discomfort
Flushing (rare)
Headache (rare)

Drug & Supplement Interactions

May interact with NAD+-dependent medications
Theoretical interaction with diabetes medications (may affect glucose metabolism)

Always inform your healthcare provider about all supplements you take.

Related Ingredients

Coenzyme Q10 (CoQ10) PQQ (Pyrroloquinoline Quinone)

Quick Facts

Dosage: General: 250-500 mg/day; Anti_Aging_Protocols: 500-1,000 mg/day
Forms: capsule sublingual tablet powder lozenge
Natural Sources: Edamame, Broccoli, Cabbage, Avocado, Cucumber, Tomato (trace amounts)
Upper Limit: Not formally established; up to 1,200 mg/day used in human trials without significant adverse e
Best Time: Morning on empty stomach or with light meal; sublingual for enhanced bioavailability

Evidence Summary

Arterial Stiffness C

Heart Failure D

FDA Disclaimer: These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.