What is the recommended dosage for Vitamin K2?

General: 90-120 mcg/day (MK-7 preferred); Cardiovascular Support: 180-360 mcg/day MK-7

What are the side effects of Vitamin K2?

Potential side effects include: Generally very well-tolerated, Does not affect blood clotting (INR) at supplemental doses, unlike K1.

What is vitamin K2 and how may it support cardiovascular health?

Vitamin K2 (menaquinone) activates matrix Gla protein (MGP), which inhibits arterial calcification. Observational studies suggest higher K2 intake is associated with reduced cardiovascular mortality and coronary calcification. The Rotterdam Study found that high K2 intake was associated with 50% lower risk of arterial calcification.

What dosage of vitamin K2 has been studied for cardiovascular benefits?

Clinical studies have used 90–360 mcg of vitamin K2 per day, primarily the MK-7 form. MK-7 has a longer half-life than MK-4, allowing once-daily dosing. Studies examining arterial stiffness and calcification typically lasted 1–3 years. K2 is often co-supplemented with vitamin D.

What are the potential side effects of vitamin K2?

K2 is generally well tolerated at supplemental doses. The critical interaction is with warfarin (and other vitamin K antagonist anticoagulants), where K2 can reduce anticoagulant efficacy. Individuals on warfarin must maintain consistent vitamin K intake and inform their healthcare provider before starting K2 supplementation.

Vitamin K2
Vitamin K2

vitamin

Aussi connu sous le nom de: Menaquinone, MK-7, MK-4, Menaquinone-7, Menaquinone-4

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About

Vitamin K2 activates matrix Gla protein (MGP), the most potent natural inhibitor of arterial calcification, directing calcium to bones and away from arteries. The Rotterdam Heart Study (4,807 participants) found the highest vitamin K2 intake was associated with 57% reduction in cardiovascular mortality and 52% reduction in severe aortic calcification.

How It Works

Activates matrix Gla protein (MGP) — the most potent natural inhibitor of arterial calcification — through gamma-carboxylation; directs calcium deposition to bones and away from arteries by activating osteocalcin (bone) and MGP (arteries); the MK-7 form has the longest half-life (72 hours) providing sustained vascular protection; works synergistically with vitamin D.

Evidence For Conditions

Pathologie	Note	Études	Participants
Arterial Stiffness	B	5	1200	Voir →

Side Effects

Generally very well-tolerated
Does not affect blood clotting (INR) at supplemental doses, unlike K1

Drug & Supplement Interactions

Warfarin (patients on warfarin should consult physician before K2 supplementation)
Vitamin D (synergistic — D increases MGP production, K2 activates it)

Informez toujours votre professionnel de santé de tous les compléments alimentaires que vous prenez.Informez toujours votre professionnel de santé de tous les compléments que vous prenez.

Related Ingredients

Vitamin D Niacin (Vitamin B3) Folate (Vitamin B9) Vitamin E

En bref

Posologie: General: 90-120 mcg/day (MK-7 preferred); Cardiovascular_Support: 180-360 mcg/day MK-7
Formes: capsule softgel liquid drops
Sources naturelles: Natto (richest source, MK-7), Gouda/Brie cheese, Egg yolks, Chicken liver, Sauerkraut
Limite supérieure: Not established (no known toxicity for K2 at supplemental doses)
Meilleur moment: With meals containing fat; can combine with vitamin D supplement

Synthèse des preuves

Arterial Stiffness B

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.