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Niacin (Vitamin B3) для High Triglycerides (Hypertriglyceridemia)

B Доказательства По меньшей мере одно рандомизированное исследование подтверждает это, с в целом согласованными результатами.

Reduces triglycerides 20-50% dose-dependently. Particularly effective for combined dyslipidemia (high TG + low HDL). Flushing limits adherence with immediate-release forms.

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            B

        

        

            
Итог

            
            
Reduces triglycerides 20-50% dose-dependently. Particularly effective for combined dyslipidemia (high TG + low HDL). Flushing limits adherence with immediate-release forms.

            
            
        

    










    

  
Key Study Findings





    

        
        

            

                
                    Randomized Controlled Trial
                
                
                
                12 weeks
                
                
            

            
                Efficacy of AI-Guided (GenAISTM) Dietary Supplement Prescriptions versus Traditional Methods for Lowering LDL Cholesterol: A …
            
            

                
                Dose: 190 mg/d
                
                
                или: None
                
                
                Outcome: Cholesterol levels
                
                
                Эффект: None
                
                
                p < 0.01
                
            

            
            
Популяция: Aged individuals

            
        

        
        

            

                
                    In Vitro
                
                
                
                
            

            
                Immediate-release niacin and a monounsaturated fatty acid-rich meal on postprandial inflammation and monocyte characteristics in …
            
            

                
                Dose: 2 g
                
                
                или: None
                
                
                Outcome: inflammation markers
                
                
                Эффект: None
                
                
                None
                
            

            
            
Популяция: Healthy volunteers

            
        

        
    







    
    

        
        

            

  
Key Statistics





            


    

        
8

        
Исследования

    

    

        
4000

        
Участники

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Оценка

    




        


        
        
        

            

  
Referenced Papers





            

                
                

                    

                        
                            Efficacy of AI-Guided (GenAISTM) Dietary Supplement Prescriptions versus Traditional Methods for Lowering LDL Cholesterol: A Randomized Parallel-Group Pilot Study.
                        
                        
                            
                                RCT
                            
                            
                            
                        
                    

                    

                        Nutrients
                        2024
                        
                        5 цитирований
                        
                    

                

                
                

                    

                        
                            Immediate-release niacin and a monounsaturated fatty acid-rich meal on postprandial inflammation and monocyte characteristics in men with metabolic syndrome.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        Clinical nutrition (Edinburgh, …
                        2023
                        
                        11 цитирований
                        
                    

                

                
                

                    

                        
                            Hypertriglyceridemia.
                        
                        
                            
                                Other
                            
                            
                            
                        
                    

                    

                        The New England …
                        2008
                        
                    

                

                
            

        

        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Часто используемые дозировки

                

                    
                    

                        
generalnutrition:

                        
14-16 mg/day

                    

                    
                    

                        
lipidmodification:

                        
1,000-2,000 mg/day (start at 500 mg/day and titrate)

                    

                    
                

                
                

                    Верхний предел: 35 mg/day for non-prescription use; prescription doses up to 3,000 mg/day under medical supervi
                

                
            

            

            
            

                
Дозировки, изученные в исследованиях

                

                    

                        
                            

                                Дозировка
                                Длительность
                                Эффект
                                N
                            

                        
                        
                            
                            

                                190 mg/d
                                12 weeks
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                            

                                2 g
                                --
                                
                                    
                                    Mixed
                                    
                                
                                --
                            

                            
                        
                    

                

            

            

            
            

                Лучшее время приёма: With dinner or at bedtime with a low-fat snack; aspirin 30 min before may reduce flushing
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Зарегистрированные побочные эффекты

                    
    
                        
                        
  • 
                            ⚠
                            Flushing (redness, warmth, itching — most common, especially immediate-release)
                        
    • 
                        
                        
  • 
                            ⚠
                            Gastrointestinal discomfort (nausea, diarrhea)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hepatotoxicity (especially extended-release at high doses)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hyperglycemia (may worsen blood sugar control)
                        
    • 
                        
                        
  • 
                            ⚠
                            Hyperuricemia (may precipitate gout)
                        
    • 
                        
                    

                

                

                
                

                    
Известные взаимодействия

                    
    
                        
                        
  • 
                            ●
                            Statins (increased risk of myopathy/rhabdomyolysis)
                        
    • 
                        
                        
  • 
                            ●
                            Blood pressure medications (additive hypotensive effect)
                        
    • 
                        
                        
  • 
                            ●
                            Diabetes medications (may counteract blood sugar control)
                        
    • 
                        
                        
  • 
                            ●
                            Anticoagulants (may increase bleeding risk)
                        
    • 
                        
                        
  • 
                            ●
                            Alcohol (may worsen flushing and hepatotoxicity)
                        
    • 
                        
                    

                

                

                
                

                    

                        Допустимый верхний уровень потребления: 35 mg/day for non-prescription use; prescription doses up to 3,000 mg/day under medical supervi
                    

                

                
            

            

                Всегда консультируйтесь с врачом перед началом приёма любых добавок.Всегда консультируйтесь с лечащим врачом перед началом приёма любой добавки.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Niacin (Vitamin B3) help with High Triglycerides (Hypertriglyceridemia)?
            
        
        

            Based on 8 studies with 4,000 participants, there is moderate evidence from clinical studies that Niacin (Vitamin B3) may support High Triglycerides (Hypertriglyceridemia) management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Niacin (Vitamin B3) should I take for High Triglycerides (Hypertriglyceridemia)?
            
        
        

            Studies have used various dosages. A commonly studied range is 14-16 mg/day. Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Niacin (Vitamin B3)?
            
        
        

            Reported side effects may include Flushing (redness, warmth, itching — most common, especially immediate-release), Gastrointestinal discomfort (nausea, diarrhea), Hepatotoxicity (especially extended-release at high doses), Hyperglycemia (may worsen blood sugar control). Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Niacin (Vitamin B3) and High Triglycerides (Hypertriglyceridemia)?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 8 peer-reviewed studies with 4,000 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  




            

                
                

                    
Другие ингредиенты для High Triglycerides (Hypertriglyceridemia)

                    

                        
                        
                            Omega-3 Fatty Acids (EPA/DHA)
                            A

                        
                        
                        
                            Omega-7 (Palmitoleic Acid)
                            C

                        
                        
                        
                            Chitosan
                            D

                        
                        
                    

                

                

                
                

                    
Niacin (Vitamin B3) для других состояний

                    

                        
                        
                            High Cholesterol (Hyperlipidemia)
                            B

                        
                        
                    

                

                
            

        

        

    


    
    






  
References

  
    
    
    
  1. 
      [1]
      Evgeny Pokushalov et al..
      Nutrients.
      2024.
      Efficacy of AI-Guided (GenAISTM) Dietary Supplement Prescriptions versus Traditional Methods for Lowering LDL Cholesterol: A Randomized Parallel-Group Pilot Study.
      doi:10.3390/nu16132023
      PubMed
    
    2. 
    
    
  2. 
      [2]
      Sergio Montserrat-de la Paz et al..
      Clin Nutr.
      2023.
      Immediate-release niacin and a monounsaturated fatty acid-rich meal on postprandial inflammation and monocyte characteristics in men with metabolic syndrome.
      doi:10.1016/j.clnu.2023.08.017
      PubMed
    
    3. 
    
    
  3. 
      [3]
      Robert Oh.
      N Engl J Med.
      2008.
      Hypertriglyceridemia.
      doi:10.1056/NEJMc072844
      PubMed
    
    4. 
    
  















    

        Отказ от ответственности FDA:
        Данные утверждения не были оценены Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов (FDA). Продукты и информация на этом сайте не предназначены для диагностики, лечения, излечения или профилактики каких-либо заболеваний. Представленные оценки доказательности основаны на нашем анализе опубликованных рецензируемых исследований и не являются медицинской консультацией. Всегда консультируйтесь с лечащим врачом перед началом приёма любых добавок.