What is the recommended dosage for Red Yeast Rice?

General: 1,200-2,400 mg/day providing 10 mg monacolin K; Lipid Support: 600 mg BID

What are the side effects of Red Yeast Rice?

Potential side effects include: Myalgia (muscle pain — same mechanism as statins), Gastrointestinal discomfort, Elevated liver enzymes (rare), Citrinin contamination risk in poorly manufactured products, Rhabdomyolysis (rare, at high doses).

What is red yeast rice and how may it support cardiovascular health?

Red yeast rice is fermented rice containing monacolin K, which is chemically identical to lovastatin. It has consistent clinical evidence for lowering LDL cholesterol. The CCSPS trial of 4,870 Chinese patients demonstrated significant reductions in cardiovascular events. However, monacolin K content varies greatly between products.

What dosage of red yeast rice has been studied for cholesterol reduction?

Clinical trials used red yeast rice preparations providing 2.4–10 mg of monacolin K per day. EU regulations limit supplements to products providing less than 3 mg monacolin K daily, while the FDA considers higher amounts as unapproved drugs. Product consistency and citrinin contamination are significant quality concerns.

What are the potential side effects of red yeast rice?

Because monacolin K is identical to lovastatin, red yeast rice carries the same risk of side effects: myopathy, rhabdomyolysis, and liver damage. Some products contain citrinin, a nephrotoxic mycotoxin. Red yeast rice may interact with drugs that interact with statins. CoQ10 depletion is possible, as with all statin-like compounds.

Red Yeast Rice
Red Yeast Rice

herb

Aussi connu sous le nom de: Monascus purpureus, Monacolin K, Xuezhikang, Hong Qu, Cholestin

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Red yeast rice contains monacolin K, chemically identical to lovastatin, which inhibits HMG-CoA reductase. The CCSPS trial (4,870 post-MI patients) demonstrated Xuezhikang reduced recurrent MI by 45% and total mortality by 33%. However, the FDA has taken enforcement action against high-monacolin K products, and product quality varies enormously — citrinin contamination is a significant concern.

How It Works

Contains monacolin K — chemically identical to lovastatin — which inhibits HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis; additional monacolins and phytosterols may provide cholesterol-lowering effects beyond monacolin K alone; isoflavones and sterols provide antioxidant and anti-inflammatory properties.

Evidence For Conditions

Pathologie	Note	Études	Participants
High Cholesterol (Hyperlipidemia)	A	22	8000	Voir →

Side Effects

Myalgia (muscle pain — same mechanism as statins)
Gastrointestinal discomfort
Elevated liver enzymes (rare)
Citrinin contamination risk in poorly manufactured products
Rhabdomyolysis (rare, at high doses)

Drug & Supplement Interactions

Statins (contraindicated — same mechanism, additive myopathy risk)
CYP3A4 inhibitors (grapefruit juice, certain antibiotics — increased monacolin K levels)
Fibrates (increased myopathy risk)
Cyclosporine (increased myopathy risk)
Niacin (increased myopathy risk at high doses)

Informez toujours votre professionnel de santé de tous les compléments alimentaires que vous prenez.Informez toujours votre professionnel de santé de tous les compléments que vous prenez.

Related Ingredients

Hawthorn Garlic Curcumin Berberine

En bref

Posologie: General: 1,200-2,400 mg/day providing 10 mg monacolin K; Lipid_Support: 600 mg BID
Formes: capsule tablet
Sources naturelles: Rice fermented with Monascus purpureus yeast
Limite supérieure: EU-regulated maximum: 10 mg monacolin K/day; quality varies dramatically between products
Meilleur moment: With dinner (cholesterol synthesis peaks overnight)

Synthèse des preuves

High Cholesterol (Hyperlipidemia) A

Avertissement FDA: Ces déclarations n'ont pas été évaluées par la Food and Drug Administration. Les produits et informations sur ce site ne sont pas destinés à diagnostiquer, traiter, guérir ou prévenir quelque maladie que ce soit. Les notes de preuve présentées sont basées sur notre analyse de la recherche publiée et évaluée par des pairs et ne constituent pas un avis médical. Consultez toujours votre professionnel de santé avant de commencer tout régime de compléments alimentaires.