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Vitamin K2 for Arterial Stiffness

B

Rotterdam Heart Study: 57% lower CV mortality with highest K2 intake. KNAPEN RCT: MK-7 (180 mcg/day, 3 years) significantly improved arterial stiffness in postmenopausal women.

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The Bottom Line

            
            
Rotterdam Heart Study: 57% lower CV mortality with highest K2 intake. KNAPEN RCT: MK-7 (180 mcg/day, 3 years) significantly improved arterial stiffness in postmenopausal women.

            
            
        

    











    
    

        
        

            

  
Key Statistics





            


    

        
5

        
Studies

    

    

        
1200

        
Participants

    

    

        
            
            ↑
            
        
        
Positive

    

    

        B

        
Grade

    




        


        
        

        
        
        

            

  
Dosage & Usage





            
mg = milligrams · mcg = micrograms (1,000× smaller) · IU = International Units


            
            

                
Commonly Used Dosages

                

                    
                    

                        
general:

                        
90-120 mcg/day (MK-7 preferred)

                    

                    
                    

                        
cardiovascularsupport:

                        
180-360 mcg/day MK-7

                    

                    
                

                
                

                    Upper limit: Not established (no known toxicity for K2 at supplemental doses)
                

                
            

            

            

            
            

                Best taken: With meals containing fat; can combine with vitamin D supplement
            

            
        

        

        
        
        

            

  
Safety & Side Effects





            

                
                

                    
Reported Side Effects

                    
    
                        
                        
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                            ⚠
                            Generally very well-tolerated
                        
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  • 
                            ⚠
                            Does not affect blood clotting (INR) at supplemental doses, unlike K1
                        
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Known Interactions

                    
    
                        
                        
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                            ●
                            Warfarin (patients on warfarin should consult physician before K2 supplementation)
                        
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                            ●
                            Vitamin D (synergistic — D increases MGP production, K2 activates it)
                        
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                        Tolerable upper intake: Not established (no known toxicity for K2 at supplemental doses)
                    

                

                
            

            

                Always consult your healthcare provider before starting any supplement.
            

        

        

        
        
        

            

  
Frequently Asked Questions





            




    
    

        
            Does Vitamin K2 help with Arterial Stiffness?
            
        
        

            Based on 5 studies with 1,200 participants, there is moderate evidence from clinical studies that Vitamin K2 may support Arterial Stiffness management. Our evidence grade is B (Good Evidence).
        

    

    
    

        
            How much Vitamin K2 should I take for Arterial Stiffness?
            
        
        

            Studies have used various dosages. A commonly studied range is 90-120 mcg/day (MK-7 preferred). Always consult your healthcare provider before starting any supplement regimen.
        

    

    
    

        
            Are there side effects of Vitamin K2?
            
        
        

            Reported side effects may include Generally very well-tolerated, Does not affect blood clotting (INR) at supplemental doses, unlike K1. Most side effects are mild and dose-dependent. Consult your doctor if you experience any adverse reactions.
        

    

    
    

        
            How strong is the evidence for Vitamin K2 and Arterial Stiffness?
            
        
        

            We rate the evidence as Grade B (Good Evidence). This rating is based on 5 peer-reviewed studies with 1,200 total participants. The overall direction of effect is positive.
        

    

    




        

        

        
        
        

            

  
Related Evidence





            

                
                

                    
Other ingredients for Arterial Stiffness

                    

                        
                        
                            NMN (Nicotinamide Mononucleotide)
                            C

                        
                        
                    

                

                

                
            

        

        

    


    
    












    

        FDA Disclaimer:
        These statements have not been evaluated by the Food and Drug Administration. The products and information on this website are not intended to diagnose, treat, cure, or prevent any disease. The evidence grades presented are based on our analysis of published peer-reviewed research and do not constitute medical advice. Always consult your healthcare provider before starting any supplement regimen.