Mechanisms of Action
Collagen Synthesis
The biological process of producing collagen protein in the body.
Collagen synthesis is a complex multi-step process requiring vitamin C (for proline and lysine hydroxylation), iron, copper, zinc, and amino acids (glycine, proline, hydroxyproline). Fibroblasts assemble procollagen molecules in the endoplasmic reticulum, which are then secreted, processed, and cross-linked into mature collagen fibrils. Collagen synthesis declines approximately 1% per year after age 20. In hair biology, type I and type III collagen provide structural support to the dermal papilla and hair follicle sheath. Vitamin C deficiency halts collagen synthesis entirely.